ExosomesanditsroleinthetumormicroenvironmentandtumordiagnosisandtreatmentapplicationsYangLei;WuMingsong;LiXueying;MedicalGeneticsDepartmentofZunyiMedicalUniversity;SpecialKeyLaboratoryofOralDiseasesResearch,HigherEducationInstitutionsofGuizhouProvince,ResearchCenterofMedicineandBiology,ZunyiMedicalUniversity;Exosomesaresmallmembranevesiclesofendocyticoriginandcanbesecretedbynormalandtumorcells.Exosomescontainavarietyofingredientssuchasproteins,lipids,mRNAsandmiRNAs.Exosomescanbetargetedtotransporttoothertissuesorcells,andparticipateintumorgrowth,metastasisandimmuneresponsethroughtheexchangeofmaterialandinformationbetweencells.ItmayserveaspotentialbioMarkersoftumordiagnosis,andhaveprofoundsignificanceinthestudyofcancerdevelopmentandtreatment.Inthisreview,wedescribethebiogenesisandcharacteristicsofexosomes,theirroleintumormicroenvironmentandapplicationinthetumordiagnosisandtreatment.【Fund】：贵州省科技厅资助项目(NO:黔科合J字[2013]2319、黔科合LH字[2014]7548);;贵州省教育厅特色药用资源研发创新团队(NO:黔科合人才团队字[2013]15);;遵义医学院博士启动基金资助项目(NO:F-655);遵义医学院遗传学扶持学科经费资助项目(NO:2012-2016)
【CateGoryIndex】：R73-3
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