Yeastsenseglucoseintheirenvironmentandaltergeneexpressiontomatchtheirnutritionalneeds.Inaglucose-richenvironment,glycolysisisactivated,glucosetransportisincreasedandgluconeogenesisrepressedtouseglucosetomakeenergy.Inaglucose-poorenvironmenttheseprocessesareregulatedintheoppositedirection.Rgt1isayeasttranscriptionfactorthathelpstoregulateglucosemetabolism,respondingtoglucoselevelsbyregulatingtranscriptionofgeneslikehexosetransporters(HXT1andHXT2)involvedinglucosemetabolism.Rgt1doesnotitselfdirectlysenseglucoselevelsbutisregulatedbyRgt2andSnf3actingthroughtheSCFubiquitinligasecomplex.TheSCFcomplex,includingGrr1andSkp1,targetsRgt1andotherproteinsfordegradationthroughligationwithubiquitin.TheactivityoftheSCFcomplexanditsABIlitytodegradeRgt1areregulatedbyRgt2andSnf3,glucosetransportersthatalsoactasglucosesensorsonthecellsurfacetoregulatetheactivityoftheSCFcomplexandRgt1.

Contributor:GlennCroston,PhD

REFERENCES:OzcanS,JohnstonM.Functionandregulationofyeasthexosetransporters.MicrobiolMolBiolRev1999Sep;63(3):554-69

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