RNA聚合酶

2021-07-28【求助】关于慢病毒的RNA聚合酶

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慢病毒的复制是不是需要它们自身生产的RNA聚合酶?和其他细胞里存在的RNA聚合酶II或III有什么不同吗?如果没什么不同,那么即使插入宿主细胞基因组内,还是可以借助宿主细胞的RNA聚合酶来进行转录的,是吗?大家多多指教!多谢!
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回复:时间:2009-10-04

Lentivirus, such as HIV-1 infects human CD4 plus cells. In the infected cells, HIV-1 reverse transcriptase performs viral cDNA synthesis using HIV-1 RNA genome as template. The double-stranded viral cDNA is then integrated into host cellular genome catalyzed by HIV-1 integrase. The integrated HIV-1 cDNA is called provirus, and the proviral DNA is transcribed into viral RNA by cellular RNA polymerases. Therefore, HIV-1 RNA polymerase major functions are different from that of cellular ones.