抗猪

BioX cell/InVivoMAb antimouse/rat IL1β/BE0246/50MG

TheB122monoclonalantibodyreactswithprecursorandmaturesecretedformsofmouseandratIL-1βa17kDapro-inflammatorycytokineproducedprimarilybymonocytes.IL-1βisanimportantmediatoroftheinflammatoryresponse,andisinvolvedinavarietyofcellularactivities,includingcellproliferation,differentiation,apoptosis,andTandBlymphocyteactivation.IL-1ismadeupofIL-1αandIL-1βwhicharetheproductsofdistinctgenes,butwhicharerecognizedbytwodistinctIL-1receptors.TheIL-1receptortypeI,an80kDatransmembraneproteinwithdemonstratedIL-1signalingfunctionandtheIL-1receptortypeII,a68kDamembraneproteinwitharelativelyshortcytoplasmictail.ThetypeIIreceptoractsasadecoytargetforIL-1,inhibitingIL-1activitiesbypreventingthebindingofIL-1tothetypeIreceptor.TheB122antibodyhasbeenreportedtoneutralizethebioactivityofnaturalorrecombinantIL-1β.

Isotype

ArmenianHamsterIgG

RecommendedInVivoPureDilutionBufferInVivoPurepH7.0DilutionBuffer
Immunogen

RecombinantmouseIL-1β

ReportedApplications
  • invivoIL-1βneutralization
  • invitroIL-1βneutralization
  • ELISA
Endotoxin
  • <2EU/mg(<0.002EU/μg)
  • DeterminedbyLALgelclottingassay
Purity
  • >95%
  • DeterminedbySDS-PAGE
Formulation
  • PBS,pH7.0
  • Containsnostabilizersorpreservatives
Sterility

0.2μMfiltered

Production

Purifiedfromtissueculturesupernatantinananimalfreefacility

Purification

ProteinG

Storage

Undilutedat4°Cinthedark

References
SDSSheet

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