Antibodygeneration:

Producedfromseraofrabbitspre-immunizedwithhighlypure(>98%)recombinantmurineIL3.Anti-murineIL3specificantibodywaspurifiedbyaffinitychromatographyemployingimmobilizedmurineIL3matrix.

Antigen:

recombinantmouseIL-3

Stability:

Thelyophilizedantibodyisstableforatleast2yearsfromdateofreceiptat-20°C.Thereconstitutedantibodyisstableforatleasttwoweeksat2-8°C.Frozenaliquotsarestableforatleast6monthswhenstoredat-20°C.

Reconstitution:

Reconstituteinsterilewatertoaconcentrationof0.1-1.0mg/mL.

Description:

IL-3isahematopoieticgrowthfactorthatpromotesthesurvival,differentiationandproliferationofcommittedprogenitorcellsofthemegakaryocyte,granulocyte-macrophage,erythroid,eosinophil,basophilandmastcelllineages.ProducedbyTcells,mastcellsandeosinophils,IL-3enhancesthrombopoieses,phagocytosis,andantibody-mediatedcellularcytotoxicity.ItsabilitytoactivatemonocytessuggeststhatIL-3mayhaveadditionalimmunoregulatoryroles.ManyoftheIL-3activitiesdependuponco-stimulationwithothercytokines.IL-3isspecies-specific,variablyglycosylatedcytokine.RecombinantmurineIL-3isa15.1kDaglobularproteincontaining135aminoacidresidues.