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凝血酶原片段 1+2 血栓性疾病早期诊断分子标志物
蚂蚁淘
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凝血酶原片段1+2是凝血酶原激活转化为凝血酶过程中释放的稳定的降解产物，血液中的凝血酶原片段1+2含量可以准确地反映凝血酶早期激活水平，可用于诊断血栓前状态和血栓性疾病以及针对相关疾病及时治疗和监测疗效。
以人凝血酶原片段1+2为例，当凝血途径启动，凝血因子X被激活转变为Xa，Xa可促使凝血酶原中Arg(327)-Thr(328)及Arg(363)-Ile(364)间的肽键同时断裂，释放凝血酶及凝血酶原片段1+2，即Ala(44)-Arg(327)。该凝血酶能够裂解酶原本身，释放出片段1（F1）和片段2（F2），序列分别为Ala(44)-Arg(198)，Ser(199)-Arg(327)（见图1）。
凝血酶原片段1+2的研究已经从实验走向临床，Cloud-CloneCorp.针对此片段研制了一系列产品，对于实验室科研客户推出了引物对，重组蛋白，特异性抗体和免疫检测试剂盒等科研产品，工业级客户推出了抗体对以及DIY试剂盒产品，以及针对临床研究客户的IVD原料产品，产品列表如下，欢迎需求的客户咨询及选购。
| CATALOGNO. | ORGANISMSPECIES | PRODUCTNAME | APPLICATIONS | |
| IncrementService | PGA710Hu01 | Homosapiens(Human) | PrimerPairforProthrombinFragment1+2(F1+2) | PCR |
| PGA710Mu01 | Musmusculus(Mouse) | PrimerPairforProthrombinFragment1+2(F1+2) | PCR | |
| PGA710Ra01 | Rattusnorvegicus(Rat) | PrimerPairforProthrombinFragment1+2(F1+2) | PCR | |
| Proteins | RPA710Hu01 | Homosapiens(Human) | RecombinantProthrombinFragment1+2(F1+2) | PositiveControl;Immunogen;SDS-PAGE;WB. |
| RPA710Mu01 | Musmusculus(Mouse) | RecombinantProthrombinFragment1+2(F1+2) | PositiveControl;Immunogen;SDS-PAGE;WB. | |
| RPA710Ra01 | Rattusnorvegicus(Rat) | RecombinantProthrombinFragment1+2(F1+2) | PositiveControl;Immunogen;SDS-PAGE;WB. | |
| Antibodies | PAA710Hu01 | Homosapiens(Human) | PolyclonalAntibodytoProthrombinFragment1+2(F1+2) | WB;IHC;ICC;IP. |
| LAA710Hu71 | Homosapiens(Human) | Biotin-LinkedPolyclonalAntibodytoProthrombinFragment1+2(F1+2) | WB;IHC;ICC. | |
| MAA710Hu21 | Homosapiens(Human) | MonoclonalAntibodytoProthrombinFragment1+2(F1+2) | WB;IHC;ICC;IP. | |
| LAA710Hu72 | Homosapiens(Human) | Biotin-LinkedMonoclonalAntibodytoProthrombinFragment1+2(F1+2) | WB;IHC;ICC. | |
| PAA710Mu01 | Musmusculus(Mouse) | PolyclonalAntibodytoProthrombinFragment1+2(F1+2) | WB;IHC;ICC;IP. | |
| PAA710Ra01 | Rattusnorvegicus(Rat) | PolyclonalAntibodytoProthrombinFragment1+2(F1+2) | WB;IHC;ICC;IP. | |
| LAA710Ra81 | Rattusnorvegicus(Rat) | FITC-LinkedPolyclonalAntibodytoProthrombinFragment1+2(F1+2) | WB;IHC;ICC;IF. | |
| LAA710Ra71 | Rattusnorvegicus(Rat) | Biotin-LinkedPolyclonalAntibodytoProthrombinFragment1+2(F1+2) | WB;IHC;ICC. | |
| AssayKits | SEA710Hu | Homosapiens(Human) | ELISAKitforProthrombinFragment1+2(F1+2) | Enzyme-linkedimmunosorbentassayforAntigenDetection. |
| SCA710Hu | Homosapiens(Human) | CLIAKitforProthrombinFragment1+2(F1+2) | ChemiluminescentimmunoassayforAntigenDetection. | |
| HEA710Hu | Homosapiens(Human) | HighSensitiveELISAKitforProthrombinFragment1+2(F1+2) | Enzyme-linkedimmunosorbentassayforAntigenDetection. | |
| SEA710Mu | Musmusculus(Mouse) | ELISAKitforProthrombinFragment1+2(F1+2) | Enzyme-linkedimmunosorbentassayforAntigenDetection. | |
| SCA710Ra | Rattusnorvegicus(Rat) | CLIAKitforProthrombinFragment1+2(F1+2) | ChemiluminescentimmunoassayforAntigenDetection. | |
| SEA710Ra | Rattusnorvegicus(Rat) | ELISAKitforProthrombinFragment1+2(F1+2) | Enzyme-linkedimmunosorbentassayforAntigenDetection. | |
| SEA710Po | Susscrofa;Porcine(Pig) | ELISAKitforProthrombinFragment1+2(F1+2) | Enzyme-linkedimmunosorbentassayforAntigenDetection. | |
| AntibodyPairs | PSA710Hu01 | Homosapiens(Human) | AntibodyPairforTroponinIType1,SlowSkeletal(TNNI1) | ELISA;CLIA;ELISPOT;Luminex;ImmunochromatographyandotherImmunoassays. |
| PSA710Mu01 | Musmusculus(Mouse) | AntibodyPairforTroponinIType1,SlowSkeletal(TNNI1) | ELISA;CLIA;ELISPOT;Luminex;ImmunochromatographyandotherImmunoassays. | |
| PSA710Ra01 | Rattusnorvegicus(Rat) | AntibodyPairforTroponinIType1,SlowSkeletal(TNNI1) | ELISA;CLIA;ELISPOT;Luminex;ImmunochromatographyandotherImmunoassays. | |
| PSA710Po01 | Susscrofa;Porcine(Pig) | AntibodyPairforTroponinIType1,SlowSkeletal(TNNI1) | ELISA;CLIA;ELISPOT;Luminex;ImmunochromatographyandotherImmunoassays. | |
| AssayKitDIYMaterials | KSA710Hu01 | Homosapiens(Human) | ELISAKitDIYMaterialsforProthrombinFragment1+2(F1+2) | Mainmaterialsfor"DoIt(ELISAKit)Yourself" |
| KSA710Mu01 | Musmusculus(Mouse) | ELISAKitDIYMaterialsforProthrombinFragment1+2(F1+2) | Mainmaterialsfor"DoIt(ELISAKit)Yourself" | |
| KSA710Ra01 | Rattusnorvegicus(Rat) | ELISAKitDIYMaterialsforProthrombinFragment1+2(F1+2) | Mainmaterialsfor"DoIt(ELISAKit)Yourself" | |
| KSA710Po01 | Susscrofa;Porcine(Pig) | ELISAKitDIYMaterialsforProthrombinFragment1+2(F1+2) | Mainmaterialsfor"DoIt(ELISAKit)Yourself" | |
| IVDRawMaterials | RSA710Hu21 | Homosapiens(Human) | Anti-ProthrombinFragment1+2(F1+2)MonoclonalAntibodyforIVDRawMaterial | ELISA;WB;IHC;Other Immunoassays. |
| RSA710Hu01 | Homosapiens(Human) | Anti-ProthrombinFragment1+2(F1+2)PolyclonalAntibodyforIVDRawMaterial | ELISA;WB;IHC;Other Immunoassays. |
表1凝血酶原片段1+2系列产品
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