Clone/ABfeature:

(#4J50)

Antibodygeneration:

Thisantibodywasproducedfromahybridoma(mousemyelomafusedwithspleencellsfromarat)immunizedwithmouserecombinantproteinofNKG2D.

Antigen:

recombinantmouseNKG2D

StABIlity:

Lyophilizedsamplesarestablefor2yearsfromdateofreceiptwhenstoredat-70°C.Reconstitutedantibodycanbealiquotedandstoredfrozenat< -20 °C for at least for six months without detectable loss of activity.

Reconstitution:

Reconstitutetheantibodywith500µlsterilePBSandthefinalconcentrationis200µg/ml.

Description:

NKG2DisatypeIItransmembraneproteinwithanextracellularC-typelectindomain.Itoccursasadisulfide-linkedhomodimerthatassociateswitheithertheDAP12orDAP10transmembraneadapterproteins.NKG2DisexpressedonNKcellsandsomeTcellsubsets,whereitfunctionsasanactivatingreceptortotriggercytolyticactivityandcytokinesecretion.LigandsforhumanNKG2DincludeMICA,MICB,andULBP-1,-2,-3,and-4.MouseNKG2DligandsincludeH60,MULT-1,andRae-1alpha,beta,gamma,delta,andepsilon.