Antigen:

RecombinantmousesolubleEndomucin(RT#S01-M64)

Stability:

Thelyophilizedantibodyisstableatroomtemperatureforupto1month.Thereconstitutedantibodyisstableforatleasttwoweeksat2-8°C.Frozenaliquotsarestableforatleast6monthswhenstoredat-20°C.

Reconstitution:

Centrifugevialpriortoopening.Reconstituteinsterilewatertoaconcentrationof0.1-1.0mg/ml.

Description:

Endomucin(endothelialsialomucin;alsoEndomucin-1/2andMucin-14)isan80-120kDaglycoproteinmemberoftheEndomucinfamilyofproteins.Itisexpressedonendothelialcellsanddependinguponitsglycosylationpattern,canserveaseitherapro-oranti-adhesivemolecule.MouseEndomucinprecursoris261aminoacidsinlength.ItistypeItransmembraneproteinthatcontainsa170aaextracellulardomain(ECD)(aa21-190)anda50aacytoplasmicregion.ThreesplicevariantsexistintheECD.Oneshowsadeletionofaa91-141,asecondshowsaoneaasubstitutionforaa91-129,andathirdshowsaoneaasubstitutionforaa129-142.Overaa21-90,mouseEndomucinshares60%and30%aaidentitywithratandhumanEndomucin,respectively.