浏览人数：384 供应商：美国PeproTech(派普泰克)公司中国代表处 诚信指数：1176点 了解更多：进入公司展台 使用范围：仅限科研使用，不能应用于临床 生物在线声明：以上所展示的信息由企业自行提供，内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。 产品详细描述 The 104 monoclonal antibody specifically reacts with the mouse CD45 molecule, the Leukocyte Common Antigen (LCA) which occurs in the alloantigen CD45.2-expressing mouse strains (C57BL/6, CBA, 129, A, AKR, C58, DBA/1, DBA/2, BALB/c, and C3H/He). The 104 monoclonal antibody does not react with the leukocytes of the CD45.1-expressing mouse strains (DA, SJL/J, RIII, and STS/A). The CD45 molecule is a member of the Protein Tyrosine Phosphatase (PTP) family, because its intracellular region contains two PTP domains. The extracellular region’s variability is caused by different levels of glycosylation, and the splicing of the 4, 5, and 6 exons. The isoforms found in the mouse strains depend on the activation state, maturation stage and cell type, and are very important in B and T lymphocytes antigen receptor signal transduction. The 104 antibody inhibits some of the B lymphocytes responses, reduces the serum IgG levels, and influences the autoimmune renal pathology. 生物在线声明：以上所展示的信息由企业自行提供，内容的真实性、准确性和合法性由发布企业负责。生物在线对此不承担任何保证责任。