Ninecurrentlyidentifiedphosphoinositide3-kinases(PI3-K)constituteasubfamilyoflipidkinasesthatcatalyzetheadditionofaphosphatemoleculeonthe3-positionoftheinositolringofphosphoinositides.Phosphatidylinositol(PtdIns),theprecursorofallphosphoinosi-tides(PI),constituteslessthan10%ofthetotallipidineukaryoticcellmembranes.Approximately5%ofcellularPIisphosphorylatedatthe4-position(PtdIns-4-P),andanother5%isphosphorylatedatboththe4-and5-positions(PtdIns-4,5-P2).However,lessthan0.25%ofthetotalinositol-containinglipidsarephosphorylatedatthe3-position,consistentwiththeideathattheselipidsexertspecificregulatoryfunctionsinsidethecell,asopposedtoastructuralfunction.HerewehavechosentohighlightagroupofthephosphoinositidetargetsofthePI3-Ksandtheirdownstreamtargets.ThedownstreameffectsofthesePI-3targetsareindicatedinthelowerbandillustratingtheimportantrolethePI3Kshaveincellfunctionandsurvival.

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REFERENCES:RamehLE,CantleyLC.Theroleofphosphoinositide3-kinaselipidproductsincellfunction.JBiolChem.1999Mar26;274(13):8347-50.

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