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Adipogen/Digoxin/CDXD0175G001/1 g

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MoreInformation
ProductDetails
Synonyms	12β-Hydroxydigitoxin;NSC95100
ProductType	Chemical
Properties
Formula	C₄₁H₆₄O₁₄
MW	780.94
CAS	20830-75-5
Source/HostChemicals	Synthetic.
PurityChemicals	≥95%(HPLC)
Appearance	Whitepowder.
Solubility	SolubleinDMSO(100mM)ormethanol.
Identity	DeterminedbyNMR.
Declaration	ManufacturedbyChemodex.
OtherProductData	ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet.
InChiKey	LTMHDMANZUZIPE-PUGKRICDSA-N
ShippingandHandling
Shipping	AMBIENT
ShortTermStorage	+4°C
LongTermStorage	-20°C
HandlingAdvice	Keepcoolanddry. Protectfromlightandmoisture.
Use/Stability	Stableforatleast2yearsafterreceiptwhenstoredat-20°C.
Documents
MSDS	No
ProductSpecificationSheet
Datasheet	DownloadPDF

CardiacglycosidefromtheleavesofDigitalislanata.Itisusedtotreatcardiacarrhythmias.ItisoftenusedasamodelsubstrateofP-glycoprotein(Pgp)(0.01-10µM)andaninhibitorofNa+/K+-ATPase.Inhibitsmembrane-boundα-subunitsoftheNa+/K+ATPasepumpinmyocytes.TheprimarymechanismofactioninvolvesinhibitionoftheNa+/K+ATPase,mainlyinthemyocardium.Thisinhibitioncausesanincreaseinintracellularsodiumlevels,resultinginareversaloftheactionofthesodium-calciumexchanger,whichcausesanincreaseintheintracellularcalciumconcentration.Thisleadstoadecreaseinheartrateandincreasedstorageofcalciuminthesarcoplasmicreticulum,causingacorrespondingincreaseinthereleaseofcalciumduringeachactionpotential.

ProductReferences

(1)R.G.Woolfson,etal.;KidneyInt.46,297(1994)|(2)S.Reddy,etal.;Curr.Opin.Cardiol.12,233(1997)|(3)K.Kjeldsen&H.Bundgaard;Ann.NYAcad.Sci.986,702(2003)|(4)M.Gheorghiade,etal.;Circulation109,2959(2004)|(5)M.Ehle,etal.;Crit.Pathw.Cardiol.10,93(2011)|(6)R.J.Biggar;Clin.CancerRes.18,2133(2012)|(7)A.M.Nader&D.R.Foster;J.Clin.Pharmacol.54,3(2014)|(8)G.A.Ewy;Am.J.Med.128,1272(2015)

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