Tonbo Biosciences/APC AntiMouse CD62L (LSelectin) (MEL14)/200621U100 /100 µg相关交流-蚂蚁淘在线

Tonbo Biosciences/APC AntiMouse CD62L (LSelectin) (MEL14)/200621U100 /100 µg

mayitao /发布时间:1628875803 /浏览量:370

TheMEL-14antibodyisspecificformouseCD62L,alsoknownasL-Selectin,acelladhesionmoleculewhichfacilitateslymphocyte“rolling”onactivatedvascularendotheliumandhomingtohighendothelialvenules(HEV)asimmunecellstransmigratefrombloodintoperipheraltissues.L-SelectinisamemberofafamilyofSelectinmoleculeswhichacttogetherwiththeintegrinfamilyofadhesionmoleculestomediateleukocyte-endothelialinteractions.L-Selectinischaracteristicallyexpressedbyneutrophils,andisalsofoundonBcells,monocytes,granulocytes,andatvaryinglevelsonnaive,effectorandmemoryTcells.Itisrapidlysheduponcellactivation,releasingintothecirculationasolubleformwhosebiologicalroleisofparticularinterestincancerbiologyresearch.

TheMEL-14antibodymaybeusedasaphenotypicmarkerforCD62Lexpressiononavarietyofimmunecelltypes.PleasenotethatCD62L(L-Selectin)itselfisalsoreferredtoasMEL-14intheliterature.

Name	APCAnti-MouseCD62L(L-Selectin)(MEL-14)
Cat.No.	20-0621
AlternativeNames	LECAM-1,Ly-22
GeneID	20343
Clone	MEL-14
Isotype	RatIgG2a,kappa
Reactivity	Mouse
CrossReactivity
Format	APC
Applications	FlowCytometry
Citations*	LeeL-F,LogronioK,TuGH,ZhaiW,NiI,MeiL,DilleyJ,YuJ,etal.2012.Proc.Natl.Acad.Sci.10.1073.(Flowcytometry). HarpJR,GilchristMA,andOnamiTM.2010.J.Immunol.185:5751-5761.(invivoblocking) FurukawaY,UmemotoE,JangMH,TohyaK,MiyasakaM,andHirataT.2008.J.Biol.Chem.283:12112-12119.(Immunoelectronmicroscopy) LiY,BrazzellJ,HerreraA,andWalcheckB.2006.108:2275-2279.(Immunoprecipitation) OchandoJC,YoppAC,YngY,GarinA,LiY,BorosP,LlodraJ,DingY,LiraSA,KriegerNR,andBrombergJS.2005.J.Immunol.174:6993-7005.(invivoblocking,Flowcytometry) ZhaoL-C,SheyM,FarnsworthM,andDaileyMO.2001.J.Biol.Chem.276:30631-30640.(Immunoprecipitation) SuzukiA,AndrewDP,GonzaloJA,FukumotoM,SpellbergJ,HashiyamaM,TakimotoH,GerwinN,WebbI,MolineuxG,AmakawaR,TadaY,WakehamA,BrownJ,McNieceI,LeyK,ButcherEC,SudaT,Gutierrez-RamosJC,andMakTK.1996.Blood.87:3550-3562.(Stamper-Woodruffassay;invivoblocking) ReichertRA,JerabekL,GallatinWM,ButcherEC,andWeissmanIL.1986.136(10):3535-3542.(Immunohistochemistry)

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