HUMAN

RAT

MOUSE

REFERENCE

SH2+andSH3+

CaplanAI.Mesenchymalstemcells.J.Orthop.Res.1991;9:641-650.

CD105+

BarryFP,etal.ThemonoclonalantibodySH-2,raisedagainsthumanmesenchymalstemcells,recognizesanepitopeonendoglin(CD105).Biochem.Biophys.Res.Commun.1999;265:134-139.

CD73+

BarryF,BoyntonR,MurphyM,ZaiaJ.TheSH-3andSH-4AntibodiesRecognizeDistinctEpitopesonCD73fromHumanMesenchymalStemCells.BiochemicalandBiophysicalResearchCommunications2001;289:519-524.

SH2+,SH3+,CD29+,CD44+,CD71+,CD90+,CD106+,CD120a+，CD124+,CD166+;ⅠⅡⅢ形胶原-、碱性磷酸酶-,osteopontin-;

脂多糖受体CD14-、CD34-CD45-。

DeanRJ.MoseleyAB.Mesenchymalstemcells:BIOLOGyandpotentialclinicaluses.ExperimHematol,2000,28:875-884

CD105+,CD73+,CD90+;

CD45-,CD34-,CD14-

orCD11b-,CD79a-

orCD19-

andHLAclassII-.

MDominici1,etal.Minimalcriteriafordefiningmultipotent

mesenchymalstromalcells.TheInternationalSocietyforCellularTherapypositionstatement.Cytotherapy.2006,8(4):315-317

CD29+andCD44+,

butCD34^_andCD45^_

HouM,etal.Transplantationofmesenchymalstemcellsfromhumanbonemarrowimprovesdamagedheartfunctioninrats.IntJCardiol.2007,115(2):220-8..

theneuralgangliosideGD2+

HumanBoneMarrowMesenchymalStromalCellsExpresstheNeuralGangliosideGD2:ANovelSurfaceMarkerforthe

IdentificationofMSCs.Blood,2006

STRO-1⁺

Encina,N.R.,etal.Immunomagneticisolationofosteoprogenitorsfromhumanbonemarrowstroma.Lab.Invest.1999,79,449-457.

NGFR+

(nervegrowthfactorreceptor)

N.Querici,etal.Isolationofbonemarrowmesenchymalstemcellsbyanti-nervegrowthfactorreceptorantibodies,Exp.Hematol.30(2002)783–791

CD11b-

(C57Bl/6mice)

PhilippeTropel,etal.Isolationandcharacterisationofmesenchymalstemcellsfromadultmousebonemarrow.ExperimentalCellResearch295(2004)395–406

CD105+

BarryFP,BoyntonRE,HaynesworthS,MurphyJM,ZaiaJ.ThemonoclonalantibodySH-2,raisedagainsthumanmesenchymalstemcells,recognizesanepitopeonendoglin(CD105).Biochem.Biophys.Res.Commun.1999;265:134-139.

CD73+

BarryF,BoyntonR,MurphyM,ZaiaJ.TheSH-3andSH-4AntibodiesRecognizeDistinctEpitopesonCD73fromHumanMesenchymalStemCells.BiochemicalandBiophysicalResearchCommunications2001;289:519-524.

CD271+

（Butitislostduringculture）

JonesEA,etal.Isolationandcharacterizationofbonemarrowmultipotentialmesenchymalprogenitorcells.ArthritisRheum.

2002;46:3349-3360.

D7Fib+

（Itisalsoexpressedonskinfibroblasts.）

JonesEA,etal.Enumerationandphenotypiccharacterizationofsynovialfluidmultipotentialmesenchymalprogenitorcellsininflammatoryanddegenerativearthritis.ArthritisRheum.

2004;50:817-827.

SH2(scr同源区2)+,SH3+

CD105+

CD73+

DominiciM,LeBK,MuellerIetal.Minimalcriteriafordefiningmultipotentmesenchymalstromalcells.TheInternationalSocietyforCellularTherapypositionstatement.Cytotherapy.2006;8:315-317.

SH-2+,B-10+,CD14-,CD45-(MSCs);

CD14-,CD45-

(marrow-derivedstromalcells,MDSCs)

MajumdarMK,etal.Phenotypicandfunctionalcomparisonofculturesofmarrow-derivedmesenchymalstemcells(MSCs)andstromalcells.JCellPhysiol,1998,176:57-60

SH2+,SH3+,CD29+,CD44+,CD71+,CD90+,CD106+,CD120a+,CD124+,andmanyothersurfaceproteins;

lipopolysaccharidereceptor-,CD14-,CD34-,andtheleukocytecommonantigenCD45-

PittengerMF.Multilineagepotentialofadulthumanmesenchymalstemcells.science,1999;284:143-146

CD1α-,CD14-,CD31-,CD34-,CD56-、CD45-,上皮特异性肌动蛋白(ESA)-

CongetPA,MinguellJJ.Phenotypicalandfunctionalpropertiesofhumanbonemarrowmesenchymalprogenitorcells.JCellPhysiol,1999,181(1):67-73.

CD29+,CD44+;CD34-CD45-

MaiHou,etal.Transplantationofmesenchymalstemcellsfromhumanbonemarrowimprovesdamagedheartfunctioninrats.InternationalJournalofCardiology,115(2007)220-228

I-HLA+,HLA-DR+,CD44+

AnVanDamme,etal.BoneMarrowStromalCellsasTargetsforGeneTherapy.CurrentGeneTherapy,2002,2,195-209

CD45-，CD146+，CD117+，Stro-1+

ShiS,GronthosS.Perivascularnicheofpostnatalmesenchymalstemcellsinhumanbonemarrowanddentalpulp.JBoneMinerRes2003;18:696-704.

CD49a+,CD133+

(α1-integrinSubunit)

CD49a+，Sca-1+

(ratsstrainLEW/CRLICO)

CD49a+,Sca-1+

(Mice,strainsBALB/cByJH-2d,C57BL/6J,FVB/N)

GindrauxF,etal.HumanandrodentbonemarrowmesenchymalstemcellsthatexpressprimitivestemcellmarkerscanbedirectlyenrichedbyusingtheCD49amolecule.CellTissueRes.2007Mar;327(3):471-483.

（differentrat）CD90+,CD44+,CD54+,CD106+,CD45-,CD11b-

Heterogeneityofstromalprecursorcellsisolatedfromratbonemarrow.Tsitologiia.2007;49(1):40-47

CD11b(-),CD45(-),andCD90(+).

(Sprague-Dawleyrats)

YoshimuraH,etal.Comparisonofratmesenchymalstemcellsderivedfrombonemarrow,synovium,periosteum,ADIposetissue,andmuscle.CellTissueRes.2007Mar;327(3):449-62.Epub2006Oct13.

Vimention+,fibronectin+

(Sprague-Dawleyrats)

Pang-YenTseng,etal.Spontaneousdifferentiationofadultratmarrowstromalcellsinalong-termculture.JVet.Med.Sci.69(2):95-102,2007.

CD11b(-),CD45(-),andCD90(+).

(Sprague-Dawleyrats)

HideyaYoshimura.Comparisonofratmesenchymalstemcellsderivedfrombonemarrow,synovium,periosteum,adiposetissue,andmuscle.CellTissueRes(2007)327:449–462

CD44+,CD106+,andCD117+,CD31-

(Sprague-Dawleyrats)

JunZhang,etal.EngineeringofVascularGraftsWithGeneticallyModifiedBoneMarrowMesenchymalStemCellsonPoly(PropyleneCarbonate)Graft.ArtifOrgans,30(12):898–905,2006

CD44+,CD90+,CD45-

(Wistarrats)

AlexandraStolzing,etal.StressedStemCells:TemperatureResponseinAgedMesenchymalStemCells.StemCellandDevelopment,15:478–487(2006)

CD34-,CD45-,CD44+,andSH3+

(Wistarrats)

YangJF,etal.TransfectionofhumanVEGF165geneintobonemarrowmesenchymalstemcellsinrats.ZhongNanDaXueXueBaoYiXueBan.2006Jun;31(3):313-8.

CD29⁺,CD34^low/-

(RatBMSCs)

XiaoHongLi,etal.Bonemarrowmesenchymalstemcellsdifferentiateintofunctionalcardiacphenotypesbycardiacmicroenvironment.JournalofMolecularandCellularCardiology42(2007)295-303

（Murine）

CD140b(PDGFRβ)

YokoKoide,etal.TwoDistinctStemCellLineagesinMurineBoneMarrow.StemCells,2007;25:1213–1221

HUMAN

RAT

MOUSE

REFERENCE

IandIIMHC-,CD34-,CD44-,CD45-,c-Kit-,

Flk-1^low,Sca-1^lowandThy-1^low

CD13^high,SSEA-I^high

CD45^-TER119^-

IandIIMHC-,CD44-,

expressedhighlevelsoftelomerase,

CD31-,CD62E-orvonWillebrandfactor(vWF)-

(SDrat)

CD45^-TER119^-

Oct-4+,Rex-1+

CD31-,CD62E-orvonWillebrandfactor(vWF)-

Jiang,Y.,etal.2002.Pluripotentnatureofadult

marrowderivedmesenchymalstemcells.Nature.

418:41–49.

CD44^-,MHC^-,Oct3a+

CD44^-,MHC^-,Oct3a+

CD44^-,MHC^-,Oct3a+

LepengZeng,etal.MultipotentAdultProgenitorCellsfromSwineBoneMarrow.Stemcells2006;24:2355–2366

CD34−,CD45−,andCD105+

(mesenchymalprecursorcells)

CD45−,CD73+,CD90+,andCD106−.

(Sprague-Dawleyrats)

SangnyonKim,etal.Neuraldifferentiationpotentialofperipheralblood-andbone-marrow-derivedprecursorcells

BrainResearch1123(2006):27–33

MHCI−,MHCII−,CD44^−/dim

R.Raedtetal.Differentiationassaysofbonemarrow-derivedMultipotentAdultProgenitorCell(MAPC)-likecellstowardsneuralcellscannotdependonmorphologyandalimitedsetofneuralmarkers.ExperimentalNeurology203(2007)542–554

CD44^-、CD45^-、HLA–I^-或

HLA-II^-、c-kit^-

CD44^-、CD45^-、HLA-I^-

或HLA-II^-、c-kit^-

(Lewisrats)

SchwartzRE,etal.Multipotentadultprogenitorcellsfrombonemarrowdifferentiateintofunctionalhepatocyte-likecells.JClinInvest,2002,109(10):1291-1302.

CD44(HCAM)+、CD54(ICAM一1)+

CongetPA，MinguellJJ．Phenotypicalandfunctionalpropertiesofhumanbonemarrowmesenchymalprogenitorcell.JCellphysiol，1999，181(1)：67-73

CD44^low,CDw90+,KDR+,Flt1+,CD13^high,CD49b+

Reyes,M.,Lund,T.,Leuvik,T.,Aguiar,D.,Koodie,L.,Verfaillie,C.M.(2001)Purificationandinvivoexpansionofpostnatalhumanmarrowmesodermalprogenitorcells.Blood98,2615-2625.

I-HLA-,HLA-DR-,CD44^low,CDw90+,KDR+,Flt1+,CD13^high,CD49b+

AnVanDamme,etal.BoneMarrowStromalCellsasTargetsforGeneTherapy.CurrentGeneTherapy,2002,2,195-209

SSEA-4+

(astage-specificembryonic

antigen)

CD45-

EunJ.Gang,etal.SSEA-4identifiesmesenchymalstemcellsfrombonemarrow.Blood.2007;109:1743-1751

MHCIandMHCII^neg,CD44^−/dim

(Wistarats)

RobrechtRaedt,etal.Differentiationassaysofbonemarrow-derivedMultipotentAdultProgenitorCell(MAPC)-likecellstowardsneuralcellscannotdependonmorphologyandalimitedsetofneuralmarkers.ExperimentalNeurology203(2007)542–554

CD44^low,MHC-I-,CD45-andCD90+

(S-Drat)

OnnikAgbulut,etal.

Canbonemarrow-derivedmultipotentadultprogenitorcellsregenerateinfarctedmyocardium?CardiovascularResearch72(2006)175–183

oct-4+andrex-1+

(C57Bl/6mice)

P.Tropeletal.Isolationandcharacterisationofmesenchymalstemcellsfromadultmousebonemarrow.ExperimentalCellResearch295(2004)395–406

CD49eandCD105

BaddooM,etal.Characterizationofmesenchymalstemcellsisolatedfrommurinebonemarrowbynegativeselection.JCellBiochem2003;89:1235–1249.

SunS,GuoZ,XiaoXetal.Isolationofmousemarrowmesenchymalprogenitorsbyanovelandreliablemethod.Stemcells2003;21:527–535.

Oct-4+;

SSEA-1^-Sca-1^lowFlk-1^lowCD45^-c-Kit^-

JiangY,etal.Pluripotencyofmesenchymalstemcellsderivedfromadultmarrow.Nature.2002;418:41-49

Sca-1+,SSEA-4+,andSSEA-3+,

butc-Kit-,CD45-,Flk-1-,and

SSEA-1-

(Rosa26-lacZtransgenicandBalb-cmice)

EunJ.Gang,etal.SSEA-4identifiesmesenchymalstemcellsfrombonemarrow.Blood.2007;109:1743-1751

CD31-,CD44-,CD45-,CD105-,Thy1.1-,Sca-1-,E-cadherin-,MHCclassI-andII-;

EpCAM^low,c-Kit^high,VLA-6^high,CD90^high.

C57BL/6(CD45.1+)mice)

MartaSerafini,etal.Hematopoieticreconstitutionbymultipotentadultprogenitorcells:precursorsto

long-termhematopoieticstemcells.TheJournalofExperimentalMedicine,204(1),2007129–139