The EarlyTox™ Cardiotoxicity Kit provides a fast, simple, and reliable fluorescence-based method for identifying cardiotoxic compounds in a biorelevant assay using stem-cell derived cardiomyocytes. Leveraging our proprietary masking technology with our novel calcium sensitive indicator, researchers can:

•     Eliminate cardiotoxic compounds and identify potential drug candidates
•     Measure 384 samples in minutes rather than hours
•     Minimize non-specific effect of dye on beat characteristics
•     Reduce well-to-well variation and improve data quality
•     Largest signal dynamic range available
•     Benchmark against three reference compounds: isoproterenol, sotalol and propranolol

 

 

Available Configurations:

Configuration	Description	Part Number
Explorer Kit	(2) Vials of Component A* (1) Bottle of dilution buffer (Component B) (1) Vial each of three reference compounds: isoproterenol, sotalol, and propranolol *Each reagent vial (Component A) is sufficient for 1 plate (96- or 384-wells). Each kit is sufficient for 2 plates.	(R8210)
Bulk Kit	(2) Vials of Component A** (1) Bottle of dilution buffer (Component B) (1) Vial each of three reference compounds: isoproterenol, sotalol, and propranolol **Each reagent vial (Component A) is sufficient for 5 plates (96-, 384- or 1536-wells). Each kit is sufficient for 10 plates.	(R8211)

 

 

Molecular Devices的EarlyTox心脏毒性试剂盒EarlyTox™心脏毒性试剂盒提供了一种快速，简单且可靠的基于荧光的方法，可使用干细胞衍生的心肌细胞在生物相关测定中鉴定心脏毒性化合物。利用我们专有的掩盖技术和新颖的钙敏感指示剂，研究人员可以：消除心脏毒性化合物并确定潜在的候选药物在数分钟而不是数小时内测量384个样本最小化染料对节拍特性的非特异性影响减少井间差异并提高数据质量最大的信号动态范围针对三种参考化合物的基准：异丙肾上腺素，索他洛尔和普萘洛尔