LKT/LEVETIRACETAM/L1784/100 mg相关交流-蚂蚁淘在线

LKT/LEVETIRACETAM/L1784/100 mg

mayitao /发布时间:1628271002 /浏览量:141

ProductIDL1784

CasNo.102767-28-2

Purity≥98%

Description
ProductInfo
ShippingandStorage
Downloads
References

Description

Levetiracetamisclinicallyusedtotreatawidevarietyofseizuredisorders,includingpartial,myoclonic,andtonic-clonicseizuresaswellasmoodandpsychiatricdisorderssuchasanxiety,autism,andTourette’ssyndrome.Levetiracetamdisplaysanticonvulsant/antiepileptic,neuromodulatory,anxiolytic,andcognitionenhancingactivities.LevetiracetambindstosynapticvesicleglycoproteinSV2A,amembraneglycoproteincommontoallsynapticandendocrinevesicles.SV2AplaysaroleinCa2+-inducedvesiclefusion,actionpotentialproliferation,normalCNSfunction,andsurvival.AlteringSV2AfunctioninhibitspresynapticCa2+release,reducesexcitatorypostsynapticpotentials,andinhibitssynaptictransmission.ThiscompoundisalsounderexaminationasapotentialtreatmentforAlzheimer’sdisease,asitreducesmemoryandlearningdeficits,synapticdysfunction,andhippocampalremodelinginatransgenicmurinemodelofthedisease.

ProductInfo

CasNo.	102767-28-2
Purity	≥98%
Formula	C₈H₁₄N₂O₂
FormulaWt.	170.21
ChemicalName	2(S)-(2-oxopyrrolidin-1-yl)butyramide
IUPACName	(2S)-2-(2-oxopyrrolidin-1-yl)butanamide
MeltingPoint	117°C
Solubility	SolubleinDMSO,water,andethanol,allto34mg/mL
Appearance	Whitetooffwhitepowder

ShippingandStorage

StoreTemp	Ambient
ShipTemp	Ambient

Downloads

MSDS	L1784MSDSPDF
InfoSheet	L1784InfoSheetPDF

References

VoglC,MochidaS,WolffC,etal.Thesynapticvesicleglycoprotein2AligandlevetiracetaminhibitspresynapticCa2+channelsthroughanintracellularpathway.MolPharmacol.2012Aug;82(2):199-208.PMID:22554805.

SanchezPE,ZhuL,VerretL,etal.LevetiracetamsuppressesneuronalnetworkdysfunctionandreversessynapticandcognitivedeficitsinanAlzheimersdiseasemodel.ProcNatlAcadSciUSA.2012Oct16;109(42):E2895-903.PMID:22869752.

FarooqMU,BhattA,MajidA,etal.Levetiracetamformanagingneurologicandpsychiatricdisorders.AmJHealthSystPharm.2009Mar15;66(6):541-61.PMID:19265183.

LynchBA,LambengN,NockaK,etal.ThesynapticvesicleproteinSV2Aisthebindingsitefortheantiepilepticdruglevetiracetam.ProcNatlAcadSciUSA.2004Jun29;101(26):9861-6.PMID:15210974.

================ 蚂蚁淘在线 ================

免责声明：本文仅代表作者个人观点，与本网无关。其创作性以及文中陈述文字和内容未经本站证实，对本文以及其中全部或者部分内容、文字的真实性、完整性、及时性本站不做任何保证或承诺，请读者仅作参考，并请自行核实相关内容