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背景资料TheNMDAreceptorsaremembersoftheglutamatereceptorfamilyofionchannelsthatalsoincludetheAMPAandKainatereceptors.
TheNMDAreceptorsareencodedbysevengenes:oneNMDAR1(orNR1)subunit,fourNR2(NR2A-NR2D)andtwoNR3(NR3A-NR3B)subunits.ThefunctionalNMDAreceptorappearstobeaheterotetramercomposedoftwoNMDAR1andtwoNMDAR2subunits.WhereastheNMDAR2subunitsthatassemblewiththeNMDAR1subunitcanbeeitherofthesamekind(i.e.twoNMDAR2Asubunits)ordifferent(oneNMDAR2AwithoneNMDAR2B).NMDAR3subunitscansubstitutetheNMDAR2subunitsintheircomplexwiththeNMDAR1subunit.
TheNMDARisuniqueamongligand-gatedionchannelsinthatitrequiresthesimultaneousbindingoftwoobligatoryagonists:glycineandglutamatethatbindtotheNMDAR1andNMDAR2bindingsitesrespectively.AnotheruniquecharacteristicoftheNMDAreceptorsistheirdependenceonmembranepotential.AtrestingmembranepotentialsthechannelsareblockedbyextracellularMg2+.NeuronaldepolarizationrelievestheMg2+blockageandallowsioninfluxintothecells.NMDAreceptorsarestronglyselectiveforCa2+influxdifferingfromtheotherglutamatereceptorionchannelsthatarenon-selectivecationchannels.
Ca2+entrythroughtheNMDARregulatesnumerousdownstreamsignalingpathwaysincludinglongtermpotentiation(amolecularmodelofmemory)andsynapticplasticitythatmayunderlielearning.Inaddition,theNMDAreceptorshavebeenimplicatedinavarietyofneurologicaldisordersincludingepilepsy,ischemicbraindamage,Parkinson’sandAlzheimer’sdisease.
NMDAreceptorsexpressionandfunctionaremodulatedbyavarietyoffactorsincludingreceptortraffickingtothesynapsesandinternalizationaswellasphosphorylationandinteractionwithotherintracellularproteins
NMDA受体1(NR1)(胞外)抗体的免疫原肽段为ETEKPRGYQMSTRLK(C)。此免疫原序列来源于385-399位氨基酸残基，该序列来源于大鼠NMDA受体1(Accession编号为P35439)。胞外,N端
保存建议艾美捷为您提供的NMDA受体1(NR1)(胞外)抗体(50ul)为室温运输，建议您收到产品后㧟20℃保存。
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