Clophosome ^®-  ClodronateLiposomes(Neutral)

Clophosome ^®,neutralclodronateliposomes,offershighlyefficientinvivomacrophage depletion.ClodronatemoleculesareencapsulatedinsmallMLVliposomesforsuperioractivity,physicalandchemicalstABIlity,andconvenienceofuse.Itisformulatedtoanexceptionallyhighclodronate/lipidratio.FreeclodronateiscleanedoutandtheLiposomalclodronate encapsulationefficiencyismorethan90%.ClophosomeliposomesremainhomogenousandsUSPendedevenafterlongtermstorageinfridge.Itisnotviscousandeasytoinject. Itismanufacturedsterile forlongtermshelf-life. 

Theproductissuitablefordosingwithvariousroutesincluding intravenous,intraperitoneal,subcutaneous,intranasal, intratrachealandetc.  Wehaveachieved80-90%macrophagedepletioninspleen(redpulpmacrophages)24hoursafterasingle0.2mLintravenousinjection.  Astartingdoseof0.15-0.2mL(i.v.ori.p.)for20-25g  animalbodyweightisrecommendedforgoodconsistencyinmacrophagedepletion.Optimizationisrecommendedforyourspecificapplications.

Specifications

Productcode:F70101C-N  

BrandName :Clophosome ^®

Active: clodronatedisodium. CAS:22560-50-5,7mg/mL

Lipidcomposition:   phosphatidylcholineandcholesterol

Bulksolution:   phosphatebufferedsucrose(20mM sodium phosphate,10%sucrose),pH7.0-7.5

Shelf-life: 6months guaranteedforunopenedvials