p38MAPKsaremembersoftheMAPKfamilythatareactivatedbyavarietyofenvironmentalstressesandinflammatorycytokines.StresssignalsaredeliveredtothiscascadebymembersofsmallGTPasesoftheRhofamily(Rac,Rho,Cdc42).AswithotherMAPKcascades,themembrane-proximalcomponentisaMAPKKK,typicallyaMEKKoramixedlineagekinase(MLK).TheMAPKKKphosphorylatesandactivatedMKK3/5,thep38MAPKkinase.MKK3/6canalsobeactivateddirectlybyASK1,whichisstimulatedbyapoptoticstimuli.P38MAKisinvolvedinregulationofHsp27andMAPKAP-2andseveraltranscriptionfactorsincludingATF2,STAT1,THEMax/Myccomplex,MEF-2,ELK-1andindirectlyCREBviaactivationofMSK1.

Contributor:CellSignalingTechnology

REFERENCES:Herlaar,E.andBrown,Z.(1999)p38MAPKsignalingcascadesininflammatorydisease.Mol.Med.Today5,439-447.Ichijo,H.(1999)Fromreceptorstostress-activatedMAPkinases.Oncogene18,6087-6093.Kyriakis,J.M.(1999)Makingtheconnection:couplingofstress-activatedERK/MAPK(extracellular-signal-regulatedkinase/mitogen-activatedproteinkinase)coresignalingmodulestoextracellularstimuliandBIOLOGicalresposese.Biochem.Soc.Symp.64,29-48.Lewis,T.S.etal(1998)SignaltransductionthroughMAPkinasecascades.Adv.CancerRes.74,49-139.LiS.,WattenbergEV.Cell-type-specificactivationofP38proteinkinasecascadesbythenoveltumorpromoterpalytoxin.ToxicalApplPharmacol1999160(2):109-119Roberson,M.S.andZhang,T.andLi,L.L.andMulvaney,J.(1999)Activationofthep38Mitogen-ACTIVAtedProteinKinasePathwaybyGonadotropin-ReleasingHormone.Endrocrinologyv.140,No.31310-1318.Tibbles,L.A.andWoodgett,J.R.(1999)Thestressactivatedproteinkinasepathways.CellMol.LifeSsci.55,1230-1254.WyskM.,etal.Requirementofmitogen-activatedproteinkinasekinase3(MKK3)fortumornecrosisfactor-inducedcytokineexpression.Proc.Natl.Acad.Sci.1999Vol96:pp3763-3768

================  蚂蚁淘在线  ================

免责声明：本文仅代表作者个人观点，与本网无关。其创作性以及文中陈述文字和内容未经本站证实，对本文以及其中全部或者部分内容、文字的真实性、完整性、及时性本站不做任何保证或承诺，请读者仅作参考，并请自行核实相关内容

版权声明：未经蚂蚁淘在线授权不得转载、摘编或利用其他方式使用上述作品。已经经本网授权使用作品的，应该授权范围内使用，并注明“来源：蚂蚁淘在线”。违反上述声明者，本网将追究其相关法律责任。