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脑脊液（Cerebrospinal Fluid, CSF）是诊断中枢神经系统感染的重要标本，目前主要依赖常规生化、染色镜检、培养和血清学检测判断病原。然而这些方法有的灵敏度、特异度有限，易受抗菌药物影响，有的周期较长，临床仍有相当一部分感染