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hnRNP H多克隆抗体
mayitao
/发布时间:1504094805 /浏览量:178
| 货号： | E-AB-31711 |
| 抗体英文名： | hnRNPHPolyclonalAntibody |
| 应用范围： | WB,IHC-p,ELISA |
| 宿主： | Rabbit |
| 适应物种： | Human,Mouse,Rat |
| 克隆性： | 否 |
| 保存条件： | Storeat-20℃.Avoidfreeze/thawcycles. |
| 亚型： | IgG |
| 免疫原： | SynthesizedpeptidederivedfromtheInternalregionofhumanhnRNPH |
| 规格： | 30μL/60μL/120μL |
| Synonyms | HNRNPH1,HNRPH,HNRPH1,HeterogeneousnuclearribonucleoproteinH,hnRNPH,HNRNPH2,FTP3,HNRPH2,HeterogeneousnuclearribonucleoproteinH2,hnRNPH2,FTP-3,HeterogeneousnuclearribonucleoproteinH,hnRNPH |
| Swissprot | P31943/P55795 |
| GeneID | 3188 |
| Source | Rabbit |
| Reactivity | Human,Mouse,Rat |
| Immunogen | SynthesizedpeptidederivedfromtheInternalregionofhumanhnRNPH |
| Application | WB,IHC-p,ELISA |
| Recommendeddilution | WB1:500-1:2000,IHC1:100-1:300,ELISA1:20000 |
| Concentration | 1mg/mL |
| Clonality | Polyclonal |
| ResearchAreas |
Properties
| Isotype | IgG |
| Purification | Affinitypurification |
| Conjugation | Unconjugated |
| CalculatedMV | 49kDa |
| ObservedMV | 49kDa |
| Storageinstructions | Storeat-20℃.Avoidfreeze/thawcycles. |
| Storagebuffer | PBSwith0.02%sodiumazide,0.5%BSAand50%glycerol,pH7.4 |
| Background | HNRNPH1encodesamemberofasubfamilyofubiquitouslyexpressedheterogeneousnuclearribonucleoproteins(hnRNPs).ThehnRNPsareRNAbindingproteinsthatcomplexwithheterogeneousnuclearRNA.Theseproteinsareassociatedwithpre-mRNAsinthenucleusandappeartoinfluencepre-mRNAprocessingandotheraspectsofmRNAmetabolismandtransport.WhileallofthehnRNPsarepresentinthenucleus,somemayshuttlebetweenthenucleusandthecytoplasm.ThehnRNPproteinshavedistinctnucleicacidbindingproperties.Theproteinencodedbythisgenehasthreerepeatsofquasi-RRMdomainsthatbindtoRNAandisverysimilartothefamilymemberHNRPF.ThisgenemaybeassociatedwithhereditarylymphedematypeI.Alternativelysplicedtranscriptvariantshavebeendescribed.HNRNPH1(HeterogeneousNuclearRibonucleoproteinH1)isaProteinCodinggene.DiseasesassociatedwithHNRNPH1includePrecursorT-CellAcuteLymphoblasticLeukemiaandHereditaryLymphedema.AmongitsrelatedpathwaysaremRNASplicing-MajorPathwayandGeneExpression.GOannotationsrelatedtothisgeneincludenucleicacidbindingandRNAbinding.AnimportantparalogofthisgeneisHNRNPH2. HNRNPH2belongstothesubfamilyofubiquitouslyexpressedheterogeneousnuclearribonucleoproteins(hnRNPs).ThehnRNPsareRNAbindingproteinsandtheycomplexwithheterogeneousnuclearRNA(hnRNA).Theseproteinsareassociatedwithpre-mRNAsinthenucleusandappeartoinfluencepre-mRNAprocessingandotheraspectsofmRNAmetabolismandtransport.WhileallofthehnRNPsarepresentinthenucleussomeseemtoshuttlebetweenthenucleusandthecytoplasm.ThehnRNPproteinshavedistinctnucleicacidbindingproperties.Theproteinencodedbythisgenehasthreerepeatsofquasi-RRMdomainsthatbindstoRNAs.ItisverysimilartothefamilymemberHNRPH1.ThisgeneisthoughttobeinvolvedinFabraydiseaseandX-linkedagammaglobulinemiaphenotype.Alternativesplicingresultsinmultipletranscriptvariantsencodingthesameprotein.Read-throughtranscriptionbetweenthislocusandtheribosomalproteinL36agenehasbeenobserved.HNRNPH2(HeterogeneousNuclearRibonucleoproteinH2)isaProteinCodinggene.DiseasesassociatedwithHNRNPH2includeMentalRetardation,X-Linked,Syndromic,BainType.AmongitsrelatedpathwaysaremRNASplicing-MajorPathwayandGeneExpression.GOannotationsrelatedtothisgeneincludenucleicacidbindingandRNAbinding.AnimportantparalogofthisgeneisHNRNPH1. |
Image
WesternBlotanalysisofvariouscellswithhnRNPHPolyclonalAntibody.
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