Tocris/PA 1 dihydrochloride/5463/50/50 mg相关交流-蚂蚁淘在线

Tocris/PA 1 dihydrochloride/5463/50/50 mg

苏州蚂蚁淘 /发布时间:1619123401 /浏览量:10

Description:PhotoswitchableENaCblocker

ChemicalName:3,5-Diamino-6-chloro-N-[imino[[4-(2-phenyldiazenyl)phenyl]amino]methyl]-2-pyrazinecarboxamidedihydrochloride

Purity:≥98%(HPLC)

BiologicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Photoswitchableepithelialsodiumchannel(ENaC)blocker(IC₅₀valuesare90and390nMforαβγandδβγENaCs,respectively,inthetransconformation).Switchesconformationfromcistotransat500nmandtranstocisat400nm.BlocksENaCswithgreaterefficacyinthecisconformation,incomparisontothetransconformation,inXenopusoocytesandHEK293tcells.PartiallyblocksδβγENaCsinthetransconformationandexhibitsnearmaximalblockofδβγENaCsinthecisconformation.Amiloridederivative.

TechnicalData

M.Wt	482.75
Formula	C₁₈H₁₆ClN₉O.2HCl
Storage	Storeat-20°C
Purity	≥98%(HPLC)
PubChemID	121513862
InChIKey	JKZVQNCSFUAMFC-UHFFFAOYSA-N
Smiles	O=C(NC(NC2=CC=C(/N=N/C3=CC=CC=C3)C=C2)=N)C1=C(N)N=C(N)C(Cl)=N1.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	48.27	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight482.75.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.07mL	10.36mL	20.71mL
5mM	0.41mL	2.07mL	4.14mL
10mM	0.21mL	1.04mL	2.07mL
50mM	0.04mL	0.21mL	0.41mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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