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Hello Bio/Torin 1/HB2253/10mg

苏州蚂蚁淘 /发布时间:1629653405 /浏览量:3

Name
Torin1
Shortdescription
Potent,selectivemTORinhibitor
BIOLOGicaldescription
Potent,selectiveandATP-competitivemTORinhibitor(IC₅₀valesare2and10nMatmTORC1andmTORC2respectively).Exhibits1000-foldselecticityformTORoverPI3Kand~100-foldselectivitywhencomparedto450otherproteinkinases.Impairscellgrowthandproliferationtoagreaterdegreethanrapamycin.
Biologicalaction
Inhibitor
Purity
>98%
Ourproductsinaction
SubmitYourCitationNow

Chemicalname
1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one
MolecularWeight
607.62
MolecularFormula
C₃₅H₂₈F₃N₅O₂
CASNumber
1222998-36-8

Storageinstructions
+4°C
Important
ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

Discoveryof1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-oneasahighlypotent,selectivemammaliantargetofrapamycin(mTOR)inhibitorforthetreatmentofcancer.
Liuetal(2010)JMedCHem53(19):7146-55
PubMedID:20860370
AnATP-competitivemammaliantargetofrapamycininhibitorrevealsrapamycin-resistantfunctionsofmTORC1.
Thoreenetal(2009)JBiolChem284(12):8023-32
PubMedID:19150980
Selectivetargetingofhumancoloncancerstem-likecellsbythemTORinhibitorTorin-1.
FrancipaneandLagasse(2013)Oncotarget4(11):1948-62
PubMedID:24185040

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Hello Bio/Torin 1/HB2253/10mg