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蚂蚁淘在线 / 品牌中心 / Medimabs / Medimabs/FGFR1c, FGFR2b, FGFR2c, FGFR3b, FGFR3c, FGFR4 Human Recombinant Antibody panel/6 vials (20 µg each)/MM-0313
商品描述
Target:
Human FGFR1c, FGFR2b, FGFR2c, FGFR3b, FGFR3c, FGFR4
Target background:
Fibroblast growth factor receptors (FGFRs) encompass a family of type I transmembrane tyrosine kinases, which undergo dimerization and phosphorylation after ligand binding. FGFRs are of therapeutic value given their involvement in tumourigenesis. Four distinct genes encoding closely related FGFRs, FGFR1‑4, have been identified. Alternatively-spliced variants that encode different protein isoforms of each of the 4 FGFR proteins include the following subset: FGFR1c, FGFR2b, FGFR2c, FGFR3b, FGFR3c and FGFR4. Using phage display technology, we identified specific binders against human targets that correspond to each of the above 6 isoforms. This FGFR family panel will allow researchers to profile each indicated FGFR isoform without cross-reacting to the other using Flow Cytometry and ELISA.
Immunogen:
ECD of recombinant protein (see individual product for more informations)
Specificity: This panel is made of 6 different antibodies in individual 20µg vials with no cross reactivities in between each isoforms tested. (see individual products for more informations)
Clone ID:
CR - 100 (generated by CCAB)
Isotype:
hIgG1; also available as mIgG1, scIgG1, schmIgG2a
Preservative:
None
Format:
Lyophilized protein A purified in PBS pH7.4; Antibody kit
Recommend starting dilution:
Reconstitute with deionized water. Optimal dilution has to be determined by the user.
Limitations:
Research Use Only; Manufactured by CCAB under a license using Life Technologies proprietary cell lines.
References:
1.-Persson H - CDR-H3 diversity is not required for antigen recognition by synthetic antibodies.
Storage:
Lyophilized antibodies can be kept at 4ºC for up to 3 months and should be kept at -20ºC for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80ºC) or kept at 4ºC for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy.
