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蚂蚁淘在线 / 品牌中心 / Medimabs / Medimabs/Huntingtin-Interacting Protein 1-Related (HIP1R) Rabbit Polyclonal Antibody/100 µL/MM-0032
商品描述
Target:
Huntingtin-Interacting Protein 1-Related (HIP1R)
Target background:
HIP1R (huntingtin interacting protein 1 related) was first cloned based on its sequence similarity with HIP1 (Huntingtin Interacting Protein 1).HIP1 binds to normal huntingtin but this interaction is lost in Huntington’s disease (HD).HIP1 also binds to components of clathrin-coated pits and vesicles and is a marker of clathrin-coated membranes.HIP1R colocalizes with and binds to actin and this interaction may link the endocytic machinery to the actin cytoskeletal dynamic processes.
Target alias:
HIP1-related protein, Huntingtin-interacting protein 12, HIP-12, HIP1R
Immunogen:
peptide in C term
Specificity: The antibody recognizes the C-terminal portion of HIP1R
Clone ID:
---
Preservative:
None
Format:
Immunogen affinity purified in glycerol/PBS pH7.4
Recommend starting dilution:
If diluted with deionized water in 100 µL: WB 1:500-1:2500; IF 1:50-1:250. Optimal dilution has to be determined by the user.
Limitations:
Research Use Only
References:
1.-Engqvist-Goldstein AE - An actin-binding protein of the Sla2/Huntingtin interacting protein 1 family is a novel component of clathrin-coated pits and vesicles.
2.-Poupon V - Clathrin light chains function in mannose phosphate receptor trafficking via regulation of actin assembly.
3.-Seki N - Cloning, expression analysis, and chromosomal localization of HIP1R, an isolog of huntingtin interacting protein (HIP1).
Storage:
Antibodies diluted in glycerol can be kept at 4ºC for up to 2 months and should be kept at -20ºC for long-term storage (1 year). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. After the maximum long-term storage period (1 year -20ºC or 2 months 4ºC) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy.
