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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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商品描述
AvailABIlity:Europe(1),USA(2),other(3)
Content:7.5mL
Content:7.5mL
Overview
TheCD14antigenisahigh-affinityreceptorforthelipopolysaccharide(LPS)andLPS-bindingprotein(LPB)complex.
CD14isstronglyexpressedonmosthumanmonocytesandmacrophages.
TheCliniMACS®CD14ProductLineconsistsofmurineanti-CD14monoclonalantibodiesconjugatedtosuperparamagneticirondextranparticles.
Onevialcontains7.5mLsterile,non-pyrogenicsolution.
TheperformanceoftheCliniMACSCD14ProductLinedependsontheindividualseparationstrategy.Forinformationonrespectivecapacities,refertotheCliniMACSUserManualorcontactyourlocalrepresentative.
PleaseinquireaboutrequiredCliniMACSSystemcomponentsandaccessories.
Disclaimer
TheCliniMACS®Systemcomponents,includingReagents,TubingSets,Instruments,andPBS/EDTABuffer,aredesigned,manufacturedandtestedunderaqualitysystemcertifiedtoISO13485.
IntheEU,theCliniMACSSystemcomponentsareavailableasCE-markedmedicaldevicesfortheirrespectiveintendeduse,unlessotherwisestated.TheCliniMACSReagentsandBiotinConjugatesareintendedforinvitrouseonlyandarenotdesignatedfortherapeuticuseordirectinfusionintopatients.TheCliniMACSReagentsincombinationwiththeCliniMACSSystemareintendedtoseparatehumancells.MiltenyiBiotecasthemanufactureroftheCliniMACSSystemdoesnotgiveanyrecommendationsregardingtheuseofseparatedcellsfortherapeuticpurposesanddoesnotmakeanyclaimsregardingaclinicalbenefit.Forthemanufacturinganduseoftargetcellsinhumansthenationallegislationandregulations-e.g.,fortheEUtheDirective2004/23/EC("humantissuesandcells"),ortheDirective2002/98/EC("humanbloodandbloodcomponents")-mustbefollowed.Thus,anyclinicalapplicationofthetargetcellsisexclusivelywithintheresponsibilityoftheuserofaCliniMACSSystem.
IntheUS,theCliniMACSCD34ReagentSystem,includingtheCliniMACSPlusInstrument,CliniMACSCD34Reagent,CliniMACSTubingSetsTSandLS,andtheCliniMACSPBS/EDTABuffer,isFDAapproved;allotherproductsoftheCliniMACSProductLineareavailableforuseonlyunderanapprovedInvestigationalNewDrug(IND)applicationorInvestigationalDeviceExemption(IDE).
CliniMACSMicroBeadsareforresearchuseonlyandnotforhumantherapeuticordiagnosticuse.Unlessotherwisespecificallyindicated,MiltenyiBiotecproductsandservicesareforresearchonlyandnotfortherapeuticordiagnosticuse.
Details
Applications
TheCliniMACSCD14ProductLinewasdevelopedfortheenrichmentofCD14+cellsfromhumanheterogeneoushematologiccellpopulationsincombinationwiththeCliniMACSSystem.
Theenrichedcellscanbeusedforthesubsequentgenerationofhumanmonocyte-deriveddendriticcells(MoDCs).1
Referencedliterature
DCsgeneratedfrommonocytesaftertheenrichmentofCD14+cellsarewellcharacterizedandhavebeenusedforactivevaccinationinmanyclinicaltrials,mainlyinsolidtumorsandhematologicalmalignancies.2-8
Basedonnewinsightintocellularinteractions,aninterestingtherapeuticoptionmightbetheadmiNISTrationofMoDCsincombinationwiththemodificationofothercellpopulations,forexample,depletionofregulatoryTcells.FurThermore,thetargetedmanipulationofMoDCs,forexample,byelectroporationwithmRNA,mightbeaverypromisingandinnovativeapproachtoimprovetheefficacyofDCs.8
从1990年，美天旎发明MACS磁珠细胞分离技术开始，我们已经发展成为一个充满朝气的多元化的公司，公司现有1200多名员工，涉及不同领域，如生物医学、物理学、机械工程和技术服务团队。我们研发和生产了一系列的优秀产品，从独特的细胞标记试剂、复杂的细胞分离和分析设备到创新性的临床应用研究系统。
美天旎的激情
美天旎一向致力于推进生物医学和细胞治疗的研究进展。我们的激情就在于研发出影响基础科研和临床应用的技术和产品。美天旎的客户也非常重视我们的信誉和多年的经验。
美天旎的产品
MACS为您提供了从基础科研到临床应用的完整产品线及完美解决方案，涉及样品制备、细胞分离和分析、分子分析、细胞培养和清血疗法相关的产品和服务。从科研工具到GMP级的试剂，美天旎提供了跨领域的应用产品，比如细胞治疗产品就是我们跨学科专家团队共同研究的成果。
美天旎的承诺
我们的口号是"Researchers working for researchers"，这是我们一直以来能够满足客户需求的源动力。通过整合研究、开发和制造过程，我们对提供高产品质量有自己独特的理解和认识。客户可以完全相信我们的专业知识和我们的技术支持及服务。
