Enzyme immunoassay for the quantitative determination of free Risankizumab (Skyrizi®) in serum and plasma.
This kit has been especially developed for the quantitative determination of risankizumab in serum and plasma samples between the Cmin and Cmax range of concentrations.
Risankizumab Drug Bank Accession Number is DB14762.
Risankizumab is a fully humanized IgG1 monoclonal antibody (mAb) that is selective for interleukin 23 (IL-23). As an interleukin-23 antagonist, Risankizumab used to treat moderate to severe plaque psoriasis, active psoriatic arthritis, and moderately to severely active Crohn"s disease in adults. Risankizumab acts to prevent the release of pro-inflammatory cytokines and chemokines that often lead to inflammatory skin symptoms, such as redness, pain, and plaques. Risankizumab binds with a high affinity to the p19 subunit of human interleukin 23 (IL-23) cytokine, thereby preventing its action on the IL-23 receptor. IL-23 is a cytokine released in the human body that is involved in inflammatory and immune processes, especially in peripheral tissues. Measurement of biological drug trough levels and antibody to biological drug gained high importance during the course of treatment. These measurements enable dose adjustments and switch to another class of biological drug when necessary.
All SHIKARI® ELISA kits are suitable for biosimilar work.
