ProductName:LCMSGradeTFA(Trifluoroaceticacid)AlternativeNames:LCMSTFA;LCMSTFAAmps;TFAAmpules;Trifluoroaceticacid;TFAAcid;CAS#76-05-1;Perfluoricacid;2,2,2-Trifluoroaceticacid;HPLCTFA

Covachem"sLCMSGradeTrifluoroaceticacid(TFA)iswellsuitedasachromatographyadditivefordifficulttoseparateanalytesinHPLCandLCMSapplications.CovaChem"sLCMSTFAisanidealadditiveforseparationsofpeptidesinpeptidesynthesisapplications.Trifluoroaceticacidiswidelyusedtoseparatebothprotectedaminoacidchainsanddeprotectedpeptides.Duetotheaminoandcarboxylategroupshavingvastlydifferentpkavalues,syntheticpeptidescanbeparticularlychallengingtoseparate,TheHPLCseparationofpeptidesismuchmoreeasilyachievedwith0.1%Trifluoroaceticacidbeingpresentinthemobilephase.

Trifluoroaceticacid(TFA)istypicallybeneficialasaseparationsenhancer,andisamoderatelystrongionpairingagent,whichcanbeaveryeffectivewayofgaininggoodanalyteseparationandobtainingsharppeaksinHPLCapplications.AlthoughTFAisandexcellentlowpHbufferforHPLCapplications,thisionpairingeffecthassomenegativeimpactonionizationefficiencies(comparedtootheracidadditives,suchasFormicacid(CovaChem11202)andAceticacid(CovaChem11201.CovaChemoffersseveralremediesfortheimpactof0.1%TFAonionization,inservinghighlyrefinedproductsthatreversethiseffect.Thisreductionofionizationefficiencycanbeovercomebyincorporatingapost-columnadditionofa“TFAfix”reagent,suchasCovaChem"sUltraPure(2-(2-methoxyethoxy)ethanol(CovaChem11207)orLCMSGradePropionicacid(CovaChem11206).Theseproductsareeasytoemploy,andallowLCMStobeperformedonpeptidesandproteinswithoutalteringHPLCmethodsthatemploy0.1%TFA.Thesetfafixreagentshavesavedcountlesshoursofhplcmethoddevelopmentandvalidationhours.Pleasefeelfreetocontactourtechnicalsupportformoreinformationonthissubject.

CovaChem"sLCMSGradeTFAcomesintwoconvenientpackagesizes(10x1mLAmpulesand25mLbottles).The1mLAmpulesofLCMSGradeTFAareusefulforquicklypreparing1Literbottlesof0.1%TFAsolutionsineitherwaterorotherorganicsolvents.

PackageSizes:10x1mLand25mL
ProductNumbers:11204-10x1or11204-25

Specifications
Appearance:Clearliquid
Purity:is≥99.5%
Storage:RoomTemperature

Properties
PhysicalState:Liquid
CAS#:76-05-1
ChemicalFormula:C2HF2O2
MolecularWeight:114.02amu
pKa:0.23
BoilingPoint:72.4°C(Lit)
Density:1.489g/mL
TariffCode:2915.90.5000

AdditionalProductInformation:
TrifluoroaceticAcid(TFA)ProductInformationBulletin
TrifluoroaceticAcid(TFA)MSDS Covachem-4-甲氧六氟丁酰氯（4-CB）描述价钱数量购买包装尺寸：5 x 1克SKU：12207-5x1$ 99.00加包装尺寸：10克SKU：12207-10$ 189.00加包装尺寸：25克SKU：12207-25$ 379.00加全部添加到购物车描述发送4-carbethoxyhexafluorobutyrl chloride（4-CB）是一种烷基化试剂，用于衍生化样品以改善气相色谱分离。在进行GC分析之前，可以使用4-CB衍生化血液样本中的苯丙胺代谢物。包装尺寸：5 x 1克和25克产品编号：12207-5x1和12207-25产品名称：4-甲氧六氟丁酰氯（4-CB）备用名称：4-Carbethoxyhexafluorobutyrl chloride; 4-CB; 乙基六氟戊二酰氯技术指标外观：无色透明液体纯度：≥98％储存：4°C，防潮特性物理状态：液体CAS＃：18381-53-8化学式：C 7 H 5 ClF 6 O 3分子量：286.56沸点：159°C（升）比重：1.47（升）