Product Description

Complement factor P (properdin) is purified from normal human serum.Factor P is a 53,000 dalton cationic protein that circulates in blood in the form of dimers, trimers and tetramers.It binds rapidly to C3b on surfaces where complement has begun to activate. Properdin binds most avidly to C3b,Bb the alternative pathway C3/C5 convertase, but also binds to C3b < C3b,B < C3b,Bb.Its primary function is to stabilize the C3b,Bb complex allowing increased alternative pathway activation (Pangburn, M.K., (1988); Nolan, K.F. and Reid, K.B.M. (1993)).Properdin enhances formation of the alternative pathway C3 convertase by increasing binding of factor B to P,C3b complexes. Thus, properdin is an accelerator (positive regulator) of complement activation.Properdin has recently been proposed to be able to also initiate activation of the alternative pathway by binding to the target surface and initiating C3/C5 convertase formation (Kemper C. and Hourcade D.E. (2008)).

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Complement Technology的GVB o是一种基本缓冲液，可用于制备用于补体测定的其他传统缓冲液。可以将Ca ++和Mg ++添加到GVB o中，以制成用于经典途径和凝集素途径测定的GVB ++。可以将MgEGTA添加到GVB o中以进行替代途径测定。EDTA可被添加到GVB Ò准备GVBE抑制补体活化。GVB ø也用于血清和其它测定组分的稀释在许多补体测定中特别是在旁路途径测定（摩根，BP（2000;多兹，AW和Sim，RB（1997））。