Product Description

The product C1s-C1INH Complex (CompTech#C1040) is made byinteracting purified protease inhibitor C1-INH (CompTech #A140) withpurified C1s enzyme (CompTech #A104) followed by purification. The protease inhibitor C1-INH prevents the spontaneous activation ofcomplement andlimits consumption of C2 and C4 by rapidly inactivatingC1r, C1s and MASP2. Itis the only plasma serine protease inhibitor(Serpin) capable of interactingwith and inhibiting activated C1.C1-INH interacts with the catalytic sites ofboth C1r and C1s. Theinteraction with activated C1r and C1s is covalentresulting incomplexes which are stable to SDS. C1s and C1r enzymes, however,areirreversibly inactivated by binding to C1-INH. C1s-C1INH (CompTech#C1040) isa very stable complex that remains intact even whensubjected to freeze/thawcycles with almost no loss of the complexform.

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Complement Technology的GVB o是一种基本缓冲液，可用于制备用于补体测定的其他传统缓冲液。可以将Ca ++和Mg ++添加到GVB o中，以制成用于经典途径和凝集素途径测定的GVB ++。可以将MgEGTA添加到GVB o中以进行替代途径测定。EDTA可被添加到GVB Ò准备GVBE抑制补体活化。GVB ø也用于血清和其它测定组分的稀释在许多补体测定中特别是在旁路途径测定（摩根，BP（2000;多兹，AW和Sim，RB（1997））。