Product Description

Many types of venom contain components that activate complement.A major component of cobra venom is CVF which binds to the victim’s factor B and this is then activated by factor D forming CVF,Bb.CVF, Bb is a serine protease specific for the victim’s C3 and often C5 as well.The activity of this C3/C5 convertase is not affected by the complement regulatory proteins in blood and the complex is extremely stable (half-life approximately 7 hours) (Morgan, B.P. ed. (2000); Law, S.K.A. and Reid, K.B.M. (1995); Nolan, K.F. and Reid, K.B.M. (1993)).It is thought that the release of C3a is important for dilation of the blood vessels near the bite and this aids dispersion of the other venom components.C5a release provides a systemic activation of numerous immune cells and inflammatory reactions.CVF from naja naja kaouthia produces an enzyme that cleaves both human C3 and C5.The affinity of the naja naja kaouthia CVF for C5 is so high that it primarily consumes C5 first, then C3.

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OUR (A150) COBRA VENOM FACTOR IS SOLD IN THE U.S.A ONLY

Complement Technology的GVB o是一种基本缓冲液，可用于制备用于补体测定的其他传统缓冲液。可以将Ca ++和Mg ++添加到GVB o中，以制成用于经典途径和凝集素途径测定的GVB ++。可以将MgEGTA添加到GVB o中以进行替代途径测定。EDTA可被添加到GVB Ò准备GVBE抑制补体活化。GVB ø也用于血清和其它测定组分的稀释在许多补体测定中特别是在旁路途径测定（摩根，BP（2000;多兹，AW和Sim，RB（1997））。