品牌分类
品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
- Specification
- Product Description:
- Mouse monoclonal antibody raised against human ANPEP.
- Immunogen:
- KG-1 myeloid cells
- Host:
- Mouse
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A/G purification
- Isotype:
- IgG1, kappa
- Recommend Usage:
- Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL)Immunofluorescence (1-2 ug/mL)Immunohistochemistry (Frozen) (0.5-1 ug/mL)The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In 10 mM PBS (0.05% BSA, 0.05% sodium azide)
- Storage Instruction:
- Store at 2 to 8°C.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Datasheet:
Download
- Applications
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Immunofluorescence
- Flow Cytometry
- Application Image
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Immunofluorescence
- Flow Cytometry
- Gene Information
- Entrez GeneID:
- 290
- Protein Accession#:
- P15144
- Gene Name:
- ANPEP
- Gene Alias:
- APN,CD13,LAP1,PEPN,gp150,p150
- Gene Description:
- alanyl (membrane) aminopeptidase
- Omim ID:
- 151530
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq
- Other Designations:
- OTTHUMP00000194690,aminopeptidase M,aminopeptidase N,membrane alanine aminopeptidase,microsomal aminopeptidase
- Gene Pathway
- Glutathione metabolism
- Hematopoietic cell lineage
- Metabolic pathways
- Renin-angiotensin system
- Related Disease
- Genetic Predisposition to Disease
- Hypertension
- Lung Neoplasms
- Tobacco Use Disorder
