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联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
- Specification
- Product Description:
- This antibody pair set comes with matched antibody pair to detect and quantify protein level of human ACVR1B.
- Reactivity:
- Human
- Quality Control Testing:
- Standard curve using recombinant protein ( H00000091-Q01 ) as an analyte.Sandwich ELISA detection sensitivity ranging from 10 ng/ml to 100 ng/ml.
- Supplied Product:
- Antibody pair set content: 1. Capture antibody: mouse monoclonal anti-ACVR1B, IgG1 Kappa (100 ug) 2. Detection antibody: biotinylated mouse monoclonal anti-ACVR1B, IgG1 Kappa (50 ug) *Reagents are sufficient for at least 3-5 x 96 well plates using recommended protocols.
- Storage Instruction:
- Store reagents of the antibody pair set at -20°C or lower. Please aliquot to avoid repeated freeze thaw cycle. Reagents should be returned to -20°C storage immediately after use.
- Datasheet:
Download
- Applications
- ELISA Pair (Recombinant protein)
- Protocol Download
- Application Image
- ELISA Pair (Recombinant protein)
- Gene Information
- Entrez GeneID:
- 91
- Gene Name:
- ACVR1B
- Gene Alias:
- ACTRIB,ACVRLK4,ALK4,SKR2
- Gene Description:
- activin A receptor, type IB
- Omim ID:
- 601300
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed. [provided by RefSeq
- Other Designations:
- activin A receptor, type II-like kinase 4,activin A type IB receptor,activin receptor-like kinase 4,serine(threonine) protein kinase receptor R2
- Gene Pathway
- Adherens junction
- Chronic myeloid leukemia
- Colorectal cancer
- Cytokine-cytokine receptor interaction
- Endocytosis
- MAPK signaling pathway
- Pancreatic cancer
- Pathways in cancer
- TGF-beta signaling pathway
- Related Disease
- Genetic Predisposition to Disease
- Head and Neck Neoplasms
- Neoplasm Recurrence, Local
- Neoplasms, Second Primary
- Obesity
- Ovarian Failure, Premature
- Polycystic Ovary Syndrome
- Puberty, Delayed
- Puberty, Precocious
- Schizophrenia
- Thrombophilia
- Tobacco Use Disorder
