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品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
- Specification
- Product Description:
- Rabbit monoclonal antibody raised against a human ABAT peptide using ARM Technology.
- Immunogen:
- A synthetic peptide of human ABAT is used for rabbit immunization.Customer or Abnova will decide on the preferred peptide sequence.
- Host:
- Rabbit
- Reactivity:
- Human
- Purification:
- Protein A
- Isotype:
- IgG
- Quality Control Testing:
- Antibody reactive against human ABAT peptide by ELISA and mammalian transfected lysate by Western Blot.
- Storage Buffer:
- In 1x PBS, pH 7.4
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- Note:
- 1. Customer may provide cell or tissue lysate for antibody screening.2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request.
- Library Construction:
- Non-fusion antibody library from rabbit spleen (ARM Technology).
- Expression:
- Overexpression vector and transfection into 293H cell line.
- Deliverable:
- Up to three rabbit IgG clones of 1 mg each will be delivered to customer.
- Datasheet:
Download
- Applications
- Western Blot (Transfected lysate)
- Protocol Download
- ELISA
- Application Image
- Western Blot (Transfected lysate)
- ELISA
- Gene Information
- Entrez GeneID:
- 18
- GeneBank Accession#:
- ABAT
- Gene Name:
- ABAT
- Gene Alias:
- FLJ17813,GABA-AT,GABAT,NPD009
- Gene Description:
- 4-aminobutyrate aminotransferase
- Omim ID:
- 137150
- Gene Ontology:
- Hyperlink
- Gene Summary:
- 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq
- Other Designations:
- GABA aminotransferase,GABA transferase,gamma-amino-N-butyrate transaminase
- Gene Pathway
- Alanine, aspartate and glutamate metabolism
- beta-Alanine metabolism
- Butanoate metabolism
- Metabolic pathways
- Propanoate metabolism
- Valine, leucine and isoleucine degradation
- Related Disease
- Asperger Syndrome
- Autistic Disorder
- Dyskinesia, Drug-Induced
- Genetic Predisposition to Disease
- Narcolepsy
- Schizophrenia
- Schizophrenia
- Schizophrenia, Paranoid
- Social Perception
- Tobacco Use Disorder
