Multiple Sclerosis (MS) is a demyelinating disease of the central nervous system (CNS). The main characteristics of the disease are focal areas of demyelination and inflammation, however the pathogenesis is unclear.Although no animal model thus far establishes all facets of human MS, Experimental Autoimmune Encephalomyelitis (EAE) represents the model most studied for the disease. Initially brain homogenates were used as antigens for immunization. Today, myelin related proteins or peptides are used in the disease.