ProductDescription
Raltegravir(Isentress)isanfirst-in-class,orally-available,oxADIazole-basedinhibitorofHIV-1integrase,inhibitingstrandtransferinvitrowithanIC50of2-7nM.[1]Itis>1000-foldmoreselectiveforHIV-1integrasewhencomparedtootherphosphoryltransferases,suchasthepolymeraseandRNaseHactivitiesofHIV-1reversetranscriptaseandthehumanpolymerasesalpha,beta,andgamma.
RaltegravirhasaIC95inhumanTlymphoidcellculturesof31nMandwasalsoactiveagainstHIV-2whentestedinCEMx174cells,withanIC95of6nM.[2]
RaltegravirhasbeenshowntobeapotentandselectiveagainstXenotropicmurineleukemia-relatedretrovirus(XMRV)atsubmicromolarconcentrationsinMCF-7breastcancer(EC50=5nM,EC90=3.5uM)andLNCaPprostatecancer(EC50=30nM,EC900.46um)celllines.[3]
Technicalinformation:
| ChemicalFormula: | C20H21FN6O5 | |
| CAS#: | 871038-72-1 | |
| MolecularWeight: | 444.42 | |
| Purity: | >98% | |
| Appearance: | White | |
| ChemicalName: | N-(4-fluorobenzyl)-5-hydroxy-1-methyl-2-(2-(2-methyl-1,3,4-oxadiazole-5-carboxamido)propan-2-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamide | |
| Solubility: | Upto100mMinDMSO | |
| Synonyms: | Raltegravir,MK-0518,MK0518,Isentress |
ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.
Reference:
| 1. | Temesgenetal.,Raltegravir:firstinclassHIVintegraseinhibitor.Ther.Clin.RiskManagement,2008,4(2),493-500.PubmedID:18728839 |
| 2. | Hicksetal.,Raltegravir:thefirstHIVtype1integraseinhibitor.Clin.Infect.Dis.2009,48(7),931-939.PubmedID:19231980 |
| 3. | Singhetal.,RaltegravirisapotentinhibitorofXMRV,avirusimplicatedinprostatecancerandchronicfatiguesyndrome.PloSONE2010,4(4),e9948.PubmedID:20376347 |
Cellagen的ChamQ SYBR qPCR预混液（无ROX）| Q321产品描述ChamQSYBR®qPCR预混液（Vazyme，＃Q321）由香槟Taq DNA聚合酶（Vazyme，＃P122）通过抗体修饰的热启动激活技术保护，是专为基于SYBR Green I的定量PCR（qPCR）设计的。ChamQSYBR®qPCR Master Mix的优化缓冲液系统中的独特因素（即促进特异性的Exactor）大大提高了其灵敏度和特异性。该混合物以2倍反应浓度制备，可直接用于鲁棒性低模板qPCR，具有高灵敏度，特异性和可靠性。优点特异性+敏感性的最佳组合。独特的抗体修饰的热启动taq，具有独特的特异性促进因子。Mg2 +和染料的最佳浓度。
