ProductDescription
LY-2484595(Evacetrapib)isabenzazepine-based,selectiveinhibitorofcholesterylestertransferprotein(CETP)atanIC50valueof5.5nMforhumanrecombinantCETP.Inhibitioninhumanplasmawas3.6nMIC50.[1]InH295Rcellsatconcentrationsupto10uM,LY-2484595hasbeenshowntoelevateHDLcholesterolwithoutinducingaldosterone,cortisolsynthesis,orincreasingbloodpressure.
Inarandomizedcontrolledtrialof398patientswithelevatedLDLandlowHDL,LY-2484595wasshowntobeeffectiveinloweringLDLandraisingHDL.Incombinationwithstatins,LY-2484595showedgreaterefficacyinloweringLDLwithnoadverseeffects.[2]
Technicalinformation:
| ChemicalFormula: | C31H36F6N6O2 | |
| CAS#: | 1186486-62-3 | |
| MolecularWeight: | 638.65 | |
| Purity: | >98% | |
| Appearance: | WhiteCrystalline | |
| ChemicalName: | Trans-4-({(5S)-5-[{[3,5-bis(trifluoromethyl)phenyl]methyl}(2-methyl-2H-tetrazol-5-yl)amino]-7,9-dimethyl-2,3,4,5-tetrahydro-1H-benzazepin-1-yl}methyl)cyclohexanecarboxylicacid | |
| Solubility: | Upto22mMinDMSO | |
| Synonyms: | LY-2484595,LY2484595,LY2484595,Evacetrapib |
ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.
Reference:
| 1. | Caoetal.,Evacetrapibisanovel,potent,andselectiveinhibitorofcholesterylestertransferproteinthatelevatesHDLcholesterolwithoutinducingaldosteroneorincreasingbloodpressure.J.LipidRes.2011,52,2169-2176.PubmedID:21957197 |
| 2. | Nichollsetal.,EffectsoftheCETPinhibitorevacetrapibadmiNISTeredasmonotherapyorincombinationwithstatinsonHDLandLDLcholesterol:arandomizedcontrolledtrial.JAMA2011,306(19),2099-2109.PubmedID:22089718 |
Cellagen的ChamQ SYBR qPCR预混液（无ROX）| Q321产品描述ChamQSYBR®qPCR预混液（Vazyme，＃Q321）由香槟Taq DNA聚合酶（Vazyme，＃P122）通过抗体修饰的热启动激活技术保护，是专为基于SYBR Green I的定量PCR（qPCR）设计的。ChamQSYBR®qPCR Master Mix的优化缓冲液系统中的独特因素（即促进特异性的Exactor）大大提高了其灵敏度和特异性。该混合物以2倍反应浓度制备，可直接用于鲁棒性低模板qPCR，具有高灵敏度，特异性和可靠性。优点特异性+敏感性的最佳组合。独特的抗体修饰的热启动taq，具有独特的特异性促进因子。Mg2 +和染料的最佳浓度。
