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商品描述
ProductDescription
Lonidamineisanorally-available,indazole-basedinhibitorofglycolysisbytheinactivationofhexokinase.LonidamineisbelievedtoincreaseapoptosisandininvitromodelshasdisplayedMarkersofmitochondrialmembranedepolarization,cytochromeCrelease,phosphatidylserineexternalization,andDNAfragmentation.Insupportofapotosisinduction,caspaseactivitywasfoundtobeenhancedbyLonidamineinLNCaPcells.(1)
Inseparatestudies,lonidaminewasfoundtoactofmitochondratoinduceapoptosisbydissipatingtheinnertransmembranepotentialandthereleaseofkeyapoptoticfactors.(2)
Technicalinformation:
| ChemicalFormula: | C15H10Cl2N2O2 | |
| CAS#: | 50264-69-2 | |
| MolecularWeight: | 321.16 | |
| Purity: | >98% | |
| Appearance: | white | |
| ChemicalName: | 1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylicacid | |
| Solubility: | Upto100mMinDMSO | |
| Synonyms: | 0 |
ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.
Reference:
| 1. | Braweretal.,Lonidamine:BasicScienceandRationaleforTreatmentofProstaticProliferativeDisorders.Rev.Urol.2005,7,suppl.7,S21-S26.PubmedID:16986057 |
| 2. | Ravagnanetal.,Lonidaminetriggersapoptosisviaadirect,Bcl-2-inhibitedeffectonthemitochondrialpermeABIlitytransitionpore.Oncogene,1999,18,2537-2546.PubmedID:10353597 |
Cellagen的ChamQ SYBR qPCR预混液（无ROX）| Q321产品描述ChamQSYBR®qPCR预混液（Vazyme，＃Q321）由香槟Taq DNA聚合酶（Vazyme，＃P122）通过抗体修饰的热启动激活技术保护，是专为基于SYBR Green I的定量PCR（qPCR）设计的。ChamQSYBR®qPCR Master Mix的优化缓冲液系统中的独特因素（即促进特异性的Exactor）大大提高了其灵敏度和特异性。该混合物以2倍反应浓度制备，可直接用于鲁棒性低模板qPCR，具有高灵敏度，特异性和可靠性。优点特异性+敏感性的最佳组合。独特的抗体修饰的热启动taq，具有独特的特异性促进因子。Mg2 +和染料的最佳浓度。
