Purmorphamine,apurine-basedagoNISToftheHedgehogsignalingpathway,selectivelyinducesosteogenesisinmultipotentmesenchymalProgenitorcells.Inaddition,purmorphamineregulatesdownstreamtargetssuchasGli1andPatched,whichledtothediscoveryofitsdirecteffectonSmoothened.[1,3]PurmorphamineactsincontrasttoknownHedgehogantagonists,suchascyclopamineandforskolin.Inaluciferase-basedassay,theEC50ofpurmorphaminewasfoundtobe0.5uM.[1]

InanindependentstudyonC3H10T1/2cells,theEC50ofpurmorphaminewasfoundtobe1uM,inducinga50-foldincreaseinalkalinephosphatase(ALP).[2,3]

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Technicalinformation:

ChemicalFormula:		C31H32N6O2
CAS#:		483367-10-8
MolecularWeight:		520.62
Purity:		>98%
Appearance:		White
ChemicalName:		9H-Purin-6-amine,9-cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-
Solubility:		Upto22mMinDMSO
Synonyms:		Purmorphamine

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ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4^oCdesiccated,orstoreDMSOsolutionat-20^oC.

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Reference:

1.	Wuetal.,Purmorphamineinducesosteogenesisbyactivationofthehedgehogsignalingpathway.Chem.Biol.2004,11,1229-1238.PubmedID:15380183
2.	Wuetal.,Asmallmoleculewithosteogenesis-inducingactivityinmultipotentmesenchymalprogenitorcells.J.Am.Chem.Soc.,2002,124,14520-14521.PubmedID:12465946
3.	Sinhaetal.,PurmorphamineactivatestheHedgehogpathwaybytargetingSmoothened.Nat.Chem.Biol.2006,2(1),29-30.PubmedID:16408088

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