GDC0980, a orally-available, thienopyrimidine-based, ATP-competitive dual inhibitor of PI3K class I isoforms (IC50 of 5, 27, 7, and 14 nM for PI3Ka, b, d, and g) and mTOR (Ki of 17 nM). [1] GDC0980 potently inhibits signal transduction (Thr308, Ser473) downstream of both PI3K and mTOR and showed most potent antitumor activity in breast, prostate, and lung cancer (IC50

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Technical information:

Chemical Formula:		C23H30N8O3S
CAS #:		1032754-93-0
Molecular Weight:		498.6
Purity:> 98%
Appearance:		White
Chemical Name:		(S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one
Solubility:		Up to 40 mM in DMSO
Synonyms:		GDC-0980, GDC0980, RG7422,

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Shipping Condition: The product is shipped in a glass vial at ambient temperature.Storage condition: For longer shelf life, store solid powder at 4^oC desiccated, or store DMSO solution at -20^oC.

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Reference:

1.	Sutherlin et al., Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer. J. Med. Chem. 2011, 54, 7579-7587. Pubmed ID:21981714
2.	Wallin et al., GDC-0980 Is a Novel Class I PI3K/mTOR Kinase Inhibitor with Robust Activity in Cancer Models Driven by the PI3K Pathway, Mol. Cancer Ther. 2011, 10, 2426-2436. Pubmed ID:21998291

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Other Information:

Product Specification (pdf) MSDS (pdf) Certificate of Analysis is available upon request.

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