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蚂蚁淘在线 / 品牌中心 / Cellagen / Cellagentech/MK-0524 (Laropiprant) | Prostaglandin D2/DP antagonist/C6052-5/5 mg (powder)
商品描述
ProductDescription
MK0524,afusedindole-basedantagoNISTofprostaglandinD2(DP),hasaKibindingaffinityof0.57nMandaKddissociationconstantof0.03nM.WiththeexceptionoftheTxA2receptor(Ki=2.95nM),MK0524hasexcellentselectivityoveranumberofotherprostanoidreceptors(EPfamily,FP,andIP).Inafunctionalactivityassayinplatelet-richplasmaandwashedplatelets,MK0524hadanIC50of0.09nM.[1]
MK-0524hasbeenshowntoblocknicotinicacid-inducedcutaneousvasodilationandalsoantagonizesprostaglandinD1(DP1)inamouseDP1functionalassayatanIC50of1.1nM.[2]
Technicalinformation:
| ChemicalFormula: | C21H19ClFNO4S | |
| CAS#: | 571170-77-9 | |
| MolecularWeight: | 435.9 | |
| Purity: >98% | ||
| Appearance: | White | |
| ChemicalName: | [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-aceticacid | |
| Solubility: | Upto50mMinDMSO | |
| Synonyms: | MK-0524,MK-0524A,MK0524,Laropiprant,Cordaptive,Tredaptive |
ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.
Reference:
| 1. | Sturinoetal.,DiscoveryofaPotentandSelectiveProstaglandinD2ReceptorAntagonist,[(3R)-4-(4-Chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-aceticAcid(MK-0524).J.Med.Chem.2007,50,794-806.PubmedID:17300164 |
| 2. | Chengetal.,AntagonismoftheprostaglandinD2receptor1suppressesnicotinicacid-inducedvasodilationinmiceandhumans.Proc.Natl.Acad.Sci.2006,103(17),6682-6687.PubmedID:16617107 |
Cellagen的ChamQ SYBR qPCR预混液（无ROX）| Q321产品描述ChamQSYBR®qPCR预混液（Vazyme，＃Q321）由香槟Taq DNA聚合酶（Vazyme，＃P122）通过抗体修饰的热启动激活技术保护，是专为基于SYBR Green I的定量PCR（qPCR）设计的。ChamQSYBR®qPCR Master Mix的优化缓冲液系统中的独特因素（即促进特异性的Exactor）大大提高了其灵敏度和特异性。该混合物以2倍反应浓度制备，可直接用于鲁棒性低模板qPCR，具有高灵敏度，特异性和可靠性。优点特异性+敏感性的最佳组合。独特的抗体修饰的热启动taq，具有独特的特异性促进因子。Mg2 +和染料的最佳浓度。
