ProductDescription
LatanoprostisapotentandselectiveagoNISTofProstaglandinFreceptor(FP).ItactivatesFP,aG-proteincoupledreceptor(GPCR),withEC50of10nM,andwithatleast500-foldselectivtyoverotherProstaglandinreceptors.(1)Uponactivation,FPpromotesthedecreaseofintraocularpressureandcontractionofsmoothmuscle.
Clinically,Latanoprost(akaXalatan(r))isusedasatopicalophthalmicsolutionforcontrollingtheprogressionofglaucomaorocularhypertensionbyincreasingtheoutflowofaqueousfluidfromtheeyes,thereforereducingintraocularpressure.(2)
Technicalinformation:
ChemicalFormula: | C26H40O5 | |
CAS#: | 130209-82-4 | |
MolecularWeight: | 432.59 | |
Purity: | >98% | |
Appearance: | clearoil | |
ChemicalName: | (Z)-isopropyl7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate | |
Solubility: | Upto100mMinDMSO | |
Synonyms: | latanoprost,Xalatan® |
ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.
Reference:
1. | Stjernschantzetal.,FromPGF2?-isopropylestertolatanoprost:areviewofthedevelopmentofxalatan:theProctorLecture.Invest.Ophthalmol.Vis.Sci.2001,42(6):1134-45.PubmedID:11328719 |
2. | CamrasCBetal.,Latanoprost,aprostaglandinanalog,forglaucomatherapy.Efficacyandsafetyafter1yearoftreatmentin198patients.LatanoprostStudyGroups.Ophthalmology.1996,103(11):1916-24.PubmedID:8942890 |
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