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Cellagentech/Latanoprost | Prostaglandin F receptor (FP) agonist/C5282-2s/2 mg (10 mM solution in DMSO)

价格
¥2780.00
货号:C5282-2s
浏览量:127
品牌:Cellagen
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商品描述
ProductDescription

LatanoprostisapotentandselectiveagoNISTofProstaglandinFreceptor(FP).ItactivatesFP,aG-proteincoupledreceptor(GPCR),withEC50of10nM,andwithatleast500-foldselectivtyoverotherProstaglandinreceptors.(1)Uponactivation,FPpromotesthedecreaseofintraocularpressureandcontractionofsmoothmuscle.

Clinically,Latanoprost(akaXalatan(r))isusedasatopicalophthalmicsolutionforcontrollingtheprogressionofglaucomaorocularhypertensionbyincreasingtheoutflowofaqueousfluidfromtheeyes,thereforereducingintraocularpressure.(2)


Technicalinformation:

ChemicalFormula: C26H40O5
CAS#: 130209-82-4
MolecularWeight: 432.59
Purity: >98%
Appearance: clearoil
ChemicalName: (Z)-isopropyl7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((R)-3-hydroxy-5-phenylpentyl)cyclopentyl)hept-5-enoate
Solubility: Upto100mMinDMSO
Synonyms: latanoprost,Xalatan®

ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.


Reference:

1.Stjernschantzetal.,FromPGF2?-isopropylestertolatanoprost:areviewofthedevelopmentofxalatan:theProctorLecture.Invest.Ophthalmol.Vis.Sci.2001,42(6):1134-45.PubmedID:11328719
2.CamrasCBetal.,Latanoprost,aprostaglandinanalog,forglaucomatherapy.Efficacyandsafetyafter1yearoftreatmentin198patients.LatanoprostStudyGroups.Ophthalmology.1996,103(11):1916-24.PubmedID:8942890

Cellagen的ChamQ SYBR qPCR预混液(无ROX)| Q321产品描述ChamQSYBR®qPCR预混液(Vazyme,#Q321)由香槟Taq DNA聚合酶(Vazyme,#P122)通过抗体修饰的热启动激活技术保护,是专为基于SYBR Green I的定量PCR(qPCR)设计的。ChamQSYBR®qPCR Master Mix的优化缓冲液系统中的独特因素(即促进特异性的Exactor)大大提高了其灵敏度和特异性。该混合物以2倍反应浓度制备,可直接用于鲁棒性低模板qPCR,具有高灵敏度,特异性和可靠性。优点特异性+敏感性的最佳组合。独特的抗体修饰的热启动taq,具有独特的特异性促进因子。Mg2 +和染料的最佳浓度。