ProductDescription
OSI-906(Linsitinib)isanorally-available,ATP-competitive,imidazopyrazine-baseddualinhibitorofIGF-R1andIRwithIC50biochemicalpotencyof35nMand75nM,respectively.[1]InvitrocellassaysrevealthatOSI-906potentlyinhibitsIGF-1R,pERK1/2,andp-70S6KatIC50sof24,28,and60nM,respectively.InHT-29andColo205CRCcells,oSI-906fullyinhibitsbothIRandIGF-1Rphosphorylation,withantiproliferativeeffectsatEC50of210nMand320nM,respectively.
Oral,invivoefficacystudies(QDx12)ofOSI-906inaLISNxenograftmodelresultedinadose-dependenteffectontumorgrowthinhibitionwith100%TGIand55%regressionat75mg/kg,and60%TGIat25mg/kg.
Technicalinformation:
| ChemicalFormula: | C26H23N5O | |
| CAS#: | 867160-71-2 | |
| MolecularWeight: | 421.49 | |
| Purity: | >98% | |
| Appearance: | Yellow | |
| ChemicalName: | (1s,3s)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutanol | |
| Solubility: | Upto100mMinDMSO | |
| Synonyms: | OSI-906,OSI906,OSI906,Linsitinib |
ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.
Reference:
| 1. | Mulvihilletal.,DiscoveryofOSI-906:aselectiveandorallyefficaciousdualinhibitoroftheIGF-1receptorandinsulinreceptor.FutureMed.Chem.2009,1(6),1153-1171.PubmedID:21425998 |
Cellagen的ChamQ SYBR qPCR预混液（无ROX）| Q321产品描述ChamQSYBR®qPCR预混液（Vazyme，＃Q321）由香槟Taq DNA聚合酶（Vazyme，＃P122）通过抗体修饰的热启动激活技术保护，是专为基于SYBR Green I的定量PCR（qPCR）设计的。ChamQSYBR®qPCR Master Mix的优化缓冲液系统中的独特因素（即促进特异性的Exactor）大大提高了其灵敏度和特异性。该混合物以2倍反应浓度制备，可直接用于鲁棒性低模板qPCR，具有高灵敏度，特异性和可靠性。优点特异性+敏感性的最佳组合。独特的抗体修饰的热启动taq，具有独特的特异性促进因子。Mg2 +和染料的最佳浓度。
