ProductDescription
XL184(Cabozantinib)isanoral,small-moleculeinhibitor,whichhaspotentactivitytowardVEGFR2(IC50=0.035nM)andMET(IC50=1.3nM),aswellasanumberofotherreceptortyrosinekinasesthathavealsobeenimplicatedintumorpathoBIOLOGy,includingRET,KIT,AXL,andFLT3[1].
Multiplereceptortyrosinekinases(RTKs)aresometimesactivatedinthesametumor.InhibitionofsingleRTKmayleadtocompensatorysignalingthatmaintainscellgrowth.Targetingmultiplekinasessimultaneouslymightovercomebothintrinsicandacquiredresistancetoantitumordrugs.XL184hasbeenshowntoinhibitphosphorylationofMETandVEGFR2,todisruptangiogenesisandcellularmigrationandinvasion,andtopromotetumorandendotheliacelldeath1.Inhibitionofc-MetwithXL184blocksself-renewalcapacityinpancreaticcancerstemcells(CSCs)[2].Inmousemodelsandpreclinicalstudies,XL184demonstratesrobustantiangiogenic,antitumor,andanti-invasiveeffects,dramaticallyalterstumorpathology,preventsthedevelopmentofmetastases,andreducestumorburden[1-3].
Technicalinformation:
| ChemicalFormula: | C28H24FN3O5 | |
| CAS#: | 849217-68-1 | |
| MolecularWeight: | 501.51 | |
| Purity: >98% | ||
| Appearance: | White | |
| ChemicalName: | N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | |
| Solubility: | Upto22mMinDMSO | |
| Synonyms: | XL184,XL-184,BMS-907351,BMS907351,Cabozantinib,Cometriq |
ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.
Reference:
| 1. | YakesFM,etal.Cabozantinib(XL184),anovelMETandVEGFR2inhibitor,simultaneouslysuppressesmetastasis,angiogenesis,andtumorgrowth.MolCancerTher.2011.10(12):2298-308.PubmedID:21926191 |
| 2. | Herreros-VillanuevaM,etal.c-Metinpancreaticcancerstemcells:Therapeuticimplications.WorldJGastroenterol.2012.18(38):5321-3.PubmedID:23082047 |
| 3. | KurzrockR,etal.ActivityofXL184(Cabozantinib),anoraltyrosinekinaseinhibitor,inpatientswithmedullarythyroidcancer.JClinOncol.2011.29(19):2660-6.PubmedID:21606412 |
Cellagen的ChamQ SYBR qPCR预混液（无ROX）| Q321产品描述ChamQSYBR®qPCR预混液（Vazyme，＃Q321）由香槟Taq DNA聚合酶（Vazyme，＃P122）通过抗体修饰的热启动激活技术保护，是专为基于SYBR Green I的定量PCR（qPCR）设计的。ChamQSYBR®qPCR Master Mix的优化缓冲液系统中的独特因素（即促进特异性的Exactor）大大提高了其灵敏度和特异性。该混合物以2倍反应浓度制备，可直接用于鲁棒性低模板qPCR，具有高灵敏度，特异性和可靠性。优点特异性+敏感性的最佳组合。独特的抗体修饰的热启动taq，具有独特的特异性促进因子。Mg2 +和染料的最佳浓度。
