ProductDescription
SU-6668(TSU-68)isanATP-competitive,oxindole-basedinhibitorofFlk-1/KDR,PDGFRb,andFGFR1phosphorylationwithKivaluesof2.1,0.008,and1.2uM,respectively.[1]Attheseinhibitorylevels,itwasshownthatSU-6668inducesantiangiogenicandproapoptoticeffectsinvivo.[2,3].OraladmiNISTrationofSU6668inducedtumorregressioninA431,PC-3,NCI-HT29,andColo205celllines,andtumorstasisinSF767TgliomaandNCI-H460celllines.[2]
Inhumanmyeloidleukemiacelllinesandacutemyeloidleukemiablasts,SU6668wasshowntoinhibitthestemcellfactor-inducedphosphorylationofc-kitandERK1/2andinducedapoptosis.[4]
Technicalinformation:
| ChemicalFormula: | C18H18N2O3 | |
| CAS#: | 252916-29-3 | |
| MolecularWeight: | 310.35 | |
| Purity: | >98% | |
| Appearance: | Orange | |
| ChemicalName: | (Z)-3-(2,4-dimethyl-5-((2-oxoindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoicacid | |
| Solubility: | Upto100mMinDMSO | |
| Synonyms: | SU6668,SU-6668,Orantinib,TSU68 |
ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.
Reference:
| 1. | Lairdetal.,SU6668isapotentantiangiogenicandantitumoragentthatinducesregressionofestablishedtumors.CancerRes.2000,60,4152-4160.PubmedID:10945623 |
| 2. | Lairdetal.,SU6668inhibitsFlk-1/KDRandPDGFRbetainvivo,resultinginrapidapoptosisoftumorvasculatureandtumorregressioninmice.FASEB,2002,16(7),681-690.PubmedID:11978732 |
| 3. | Marzolaetal.,InvivoassessmentofantiangiogenicactivityofSU6668inanexperimentalcoloncarcinomamodel.Clin.CancerRes.2004,10,739-750.PubmedID:14760097 |
| 4. | Smolichetal.,TheantiangiogenicproteinkinaseinhibitorsSU5416andSU6668inhibittheSCFreceptor(c-kit)inahumanmyeloidleukemiacelllineandinacutemyeloidleukemiablasts.Blood,2001,97,1413-1421.PubmedID:11978732 |
Cellagen的ChamQ SYBR qPCR预混液（无ROX）| Q321产品描述ChamQSYBR®qPCR预混液（Vazyme，＃Q321）由香槟Taq DNA聚合酶（Vazyme，＃P122）通过抗体修饰的热启动激活技术保护，是专为基于SYBR Green I的定量PCR（qPCR）设计的。ChamQSYBR®qPCR Master Mix的优化缓冲液系统中的独特因素（即促进特异性的Exactor）大大提高了其灵敏度和特异性。该混合物以2倍反应浓度制备，可直接用于鲁棒性低模板qPCR，具有高灵敏度，特异性和可靠性。优点特异性+敏感性的最佳组合。独特的抗体修饰的热启动taq，具有独特的特异性促进因子。Mg2 +和染料的最佳浓度。
