PD0325901 is the selective inhibitor of mitogen activated protein kinase kinase (MEK or MAPKK) with IC50 about 1nM against activated MEK1 and MEK2. Its potency, solubility and effectiveness are all much better than CI-1040. Anticancer activity of PD0325901 has been demonstrated for a broad spectrum of human tumor xenografts. When using with GSK-3β inhibitor CHIR99021, PD0325901 could prevent cell differentiation and sustain ES cell self-renewal.

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Technical information:

Chemical Formula:		C16H14F3IN2O4
CAS #:		391210-10-9
Molecular Weight:		482.19
Purity:		>98%
Appearance:		Off white solid
Chemical Name:		N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2[(2-fluoro-4-iodophenyl)amino]-benzamide
Solubility:		Up to 50 mM in DMSO

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Shipping Condition: The product is shipped in a glass vial at ambient temperature.Storage: For longer shelf life, store solid powder at 4^oC desiccated, or store DMSO solution at -20^oC.

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Reference:

1.	Barrett, S.D., et al. The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901. Bioorg. Med. Chem. Lett. (2008), 18: 6501-6504.
2.	Judith S. Sebolt-Leopold et al. The biological profile of PD 0325901: A second generation analog of CI-1040 with improved pharmaceutical potential . Proc Amer Assoc Cancer Res, Volume 45, 2004.
3.	Tongxiang Lin, et al. A chemical platform for improved induction of human iPSCs. Nature Methods 6, 805 - 808 (2009)

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Other Information:

Product Specification (pdf)MSDS (pdf)

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