ProductDescription
KU55933isanATP-competitive,thioanthrene-pyranone-basedinhibitorofATMkinasewithanIC50of13nMandKiof2.2nMand>100-foldselectivityoverPI3Krelatedkinases.[1]KU55933inhibitscellproliferationbyinducingG1cellcyclearrestbydownregulationofcyclinD1synthesisinMDA-MB-453breastcancercellsandPC-3prostatecancercells.[2]KU55933inhibitsinsulin-andIGF1-stimulatedAktphosphorylationatbothSer473andThr308.[2]ATMcellularinhibitionbyKU55933wasdemonstratedinadditionalphosphorylationtargets,includingp53Ser15,H2AXSer139,NBS1Ser343,Chk1Ser345,andSMC1Ser966.[1]
KU55933isbeingstudiedasarADIosensitizer,havingbeenshowntosensitizeHeLacellstotheeffectsoftopoisomeraseinhibitors,etoposide,doxorubicin,amsacrine,andcamptothecin.[1]Whenincombinationwithrapamycin,KU55933inducesapoptosisandarrestsanyinducedfeedbackactivationofAkt.[2]
Technicalinformation:
| ChemicalFormula: | C21H17NO3S2 | |
| CAS#: | 587871-26-9 | |
| MolecularWeight: | 395.49 | |
| Purity: | >98% | |
| Appearance: | White | |
| ChemicalName: | 2-morpholino-6-(thianthren-1-yl)-4H-pyran-4-one | |
| Solubility: | Upto100mMinDMSO | |
| Synonyms: | KU-55933,KU55933,KU55933 |
ShippingCondition:Theproductisshippedinaglassvialatambienttemperature.
Storagecondition:Forlongershelflife,storesolidpowderat4oCdesiccated,orstoreDMSOsolutionat-20oC.
Reference:
| 1. | Hicksonetal.,Identificationandcharacterizationofanovelandspecificinhibitoroftheataxia-telangiectasiamutatedkinaseATM.CancerRes.2004,64(24),9152-9159.PubmedID:15604286 |
| 2. | Lietal.,TheATMinhibitorKU-55933suppressescellproliferationandinducesapoptosisbyblockingAktincancercellswithoveractivatedAkt.Mol.Cancer.Ther.2010,9(1),113-125.PubmedID:20053781 |
Cellagen的ChamQ SYBR qPCR预混液（无ROX）| Q321产品描述ChamQSYBR®qPCR预混液（Vazyme，＃Q321）由香槟Taq DNA聚合酶（Vazyme，＃P122）通过抗体修饰的热启动激活技术保护，是专为基于SYBR Green I的定量PCR（qPCR）设计的。ChamQSYBR®qPCR Master Mix的优化缓冲液系统中的独特因素（即促进特异性的Exactor）大大提高了其灵敏度和特异性。该混合物以2倍反应浓度制备，可直接用于鲁棒性低模板qPCR，具有高灵敏度，特异性和可靠性。优点特异性+敏感性的最佳组合。独特的抗体修饰的热启动taq，具有独特的特异性促进因子。Mg2 +和染料的最佳浓度。
