AZ628 is a quinazolinone-based pan-Raf kinase inhibitor with IC50 values of 105, 34, and 29 nM for b-Raf, bRafV600E, and c-Raf-1, respectively. [1] It is selective over a wide panel of RTKs, including VEGFR2, DDR2, Lyn, Flt1, and FMS. AZ628 inhibits anchorage-dependent and -independent growth, causes cell cycle arrest, and induces apoptosis in colon and melanoma cell lines with the b-RafV600E mutation. Cross-reactivity profiles of AZ628 indicate similarities to sorafenib.Typically AZ628-sensitive lines are often characterized by b-RAFV600E or NRAS mutations, while HRAS or KRAS mutations were not normally observed. AZ628 sensitivity is correlates with its abaility to suppress downstream ERK. [2]

---

Technical information:

Chemical Formula:		C27H25N5O2
CAS #:		878739-06-1
Molecular Weight:		451.52
Purity:		> 99%
Appearance:		White
Chemical Name:		3-(2-cyanopropan-2-yl)-N-(4-methyl-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenyl)benzamide
Solubility:		Up to 22 mM in DMSO
Synonyms:		AZ-628, AZ 628, AZ628

---

Shipping Condition: The product is shipped in a glass vial at ambient temperature.Storage condition: For longer shelf life, store solid powder at 4^oC desiccated, or store DMSO solution at -20^oC.

---

Reference:

1.	Khazak et al., Selective Raf inhibition in cancer therapy. Expert Opin. Ther. Targets, 2007, 11(12), 1587-1609. Pubmed ID:18020980
2.	McDermott et al., Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling. Proc. Natl. Acad. Sci. 104(50), 19936-19941. Pubmed ID:18077425

---

Other Information:

Product Specification (pdf) MSDS (pdf) Certificate of Analysis is available upon request.

Cellagen的ChamQ SYBR qPCR预混液（无ROX）| Q321产品描述ChamQSYBR®qPCR预混液（Vazyme，＃Q321）由香槟Taq DNA聚合酶（Vazyme，＃P122）通过抗体修饰的热启动激活技术保护，是专为基于SYBR Green I的定量PCR（qPCR）设计的。ChamQSYBR®qPCR Master Mix的优化缓冲液系统中的独特因素（即促进特异性的Exactor）大大提高了其灵敏度和特异性。该混合物以2倍反应浓度制备，可直接用于鲁棒性低模板qPCR，具有高灵敏度，特异性和可靠性。优点特异性+敏感性的最佳组合。独特的抗体修饰的热启动taq，具有独特的特异性促进因子。Mg2 +和染料的最佳浓度。