Human conjunctiva is a translucent membrane that lines the inner surface of the eyelids and covers the sclera. Its coverage comprises two layers of stratified, non-keratinized conjunctival epithelial cells (ConEpiC). Human Conjunctival Epithelial Cells are different than the corneal epithelium by a specific expression profile of keratins. ConEpiC coverage comprises mucin-rich glycocalyx, which has differente functions; such as promotion of tear adherence, prevention of pathogen penetrance, and provision of lubrication. Decrease or loss of mucin/glycocalyx production generates squamous metaplasia, which may lead to dry eye and ocular surface diseases. ConEpiC also respond to histamine by stimulating phosphatidylinositol turnover and secreting cytokines, and as a result may be a good target when developing topical ocular drugs to treat allergic conjunctivitis