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indoor biotechnologies/Natural Ara h 6 (NA-AH6-1)/1/NA-AH6-1

价格
¥12100.00
货号:NA-AH6-1
浏览量:127
品牌:indoor biotechnologies
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商品描述
Allergen:nAra h 6 (Arachis hypogaea allergen 6), peanut
Unit:250µg
Source: Light roasted peanut flour (Runner cultivar)
Mol. Wt:14.5 kD
Purification:

From delipidated peanut extract by multi-step chromatography. Purity on silver stained SDS-PAGE >95%.

Concentration:See Product Insert.
Formulation:

Preservative-free and carrier-free in phosphate buffered saline, pH 7.4. Sterile filtered.

Storage:Store at -20ºC
Notes:

Trace Ara h 1 and Ara h 2 levels <0.05%.

PDB:
Product Resources:Natural Ara h 6 Certificate of Analysis
Allergens are provided for research and commercial use in vitro: not for human in vivo or therapeutic use.
References:
  1. Kleber-Janke T, Crameri R, Appenzeller U, Schlaak M, Becker WM. Selective cloning of peanut allergens, including profilin and 2S albumins, by phage display technology. Int Arch Allergy Immunol 1999; 119: 265-74.
  2. Suhr M, Wicklein D, Lepp U, Becker W. Isolation and characterization of natural Ara h 6: Evidence for a further peanut allergen with putative clinical relevance based on resistance to pepsin digestion and heat. Mol Nutr Food Res 2004; 48: 390-9.
  3. Koppelman S, de Jong G, Laaper-Ertmann M, Peeters K, Knulst A, Hefle S, Knol E. Purification and immunoglobulin E-binding properties of peanut allergen Ara h 6: evidence for cross-reactivity with Ara h 2. Clin Exp Allergy 2005; 35: 490-7.
  4. Peeters KA, Koppelman SJ, van Hoffen E, van der Tas CW, den Hartog Jager CF, Penninks AH, Hefle SL, Bruijnzeel-Koomen CA, Knol EF, Knulst AC. Does skin prick test reactivity to purified allergens correlate with clinical severity of peanut allergy? Clin Exp Allergy. 2007 Jan;37(1):108-15.
  5. Flinterman AE, van Hoffen E, den Hartog Jager CF, Koppelman S, Pasmans SG,Hoekstra MO, Bruijnzeel-Koomen CA, Knulst AC, Knol EF. Children with peanut allergy recognize predominantly Ara h2 and Ara h6, which remains stable over time. Clin Exp Allergy. 2007 Aug;37(8):1221-8.
  6. Porterfield HS, Murray KS, Schlichting DG, Chen X, Hansen KC, Duncan MW, Dreskin SC. Effector activity of peanut allergens: critical role for Ara h 2, Ara h 6, and their variants. Clin Exp Allergy 2009; 39: 1099-108.
  7. Blanc F, Adel-Patient K, Drumare M, E, Wal J, Bernard H. Capacity of purified peanut allergens to induce degranulation in a functional in vitro assay: Ara h 2 and Ara h 6 are the most efficient elicitors. Clin Exp Allergy 2009; 39: 1277-85.
  8. Flinterman AE, Pasmans S, den Hartog Jager CF, Hoekstra MO, Bruijnzeel-Koomen C, Knol EF, van Hoffen E. T cell responses to major peanut allergens in children with and without peanut allergy. Clin Exp Allergy 2010; 40: 590-7.
indoor biotechnologies很高兴将其重组蛋白的开发工作扩展到包括与过敏和哮喘有关的病毒蛋白。人鼻病毒16(HRV-16)表面蛋白VP1,VP2和VP0(VP2和VP4的融合体)被高质量生产。HRV衣壳蛋白提供了有用的工具,可用于研究鼻病毒诱发的哮喘加重所涉及的免疫机制,以及用于表位作图,T细胞反应和诊断目的。由于广泛的蛋白质-蛋白质相互作用,鼻病毒蛋白质难以单独表达。通过使用专有的纯化和制造方案,Indoor Biotechnologies开发了许多HRV-16 VP1,VP2和VP0,这些均已通过Western blotting验证。