Description:Mouse monoclonal antibody to human luteinizing hormone (LH)

Purification:Protein G affinity purified

Product Type:Primary antibody- capture antibody in matched antibody pair

Target Protein:Human LH αsubunit

Immunogen:Human LH αsubunit

Fusion Myeloma:Not known

Specificity:Human LH αsubunit

Species Reacitvity: Human, others not tested

Host / Isotype: Mouse, IgG1 Kappa

Formulation:Lyophilized from a solution in 0.01M PBS, pH 7.2

Reconstitution:Double distillated water is recommended to adjust the final concentration to 1.00 mg/mL.

Storage: Store at -20^oC

Research Area:Hormone, ovulation

Background:

In the female menstrual cycle, during a 24-48 hour period, luteinizing hormone (LH) is rapidly released from gonadotropic cells in pituitary gland as a result of positive feedback regulation by the elevated estrogen during follicle maturation. The LH surge triggers the release of mature egg from ovarian follicle and the development of remaining follicle into corpus luteum. Progesterone secreted by corpus luteum is needed for preparing the endometrium for egg implantation. LH is critical for ovulation in women. In men, LH stimulates testis to produce testosterone.

LH has an αsubunit that is identical to the one in other glycoprotein hormones such as TSH, FSH and HCG. LH level is used for predicating ovulation in women to increase the chance of insemination.

Application:

ELISA:In combination with HRP conjugated anti-LH b mAb LH-2 (MO-M40048T), the antibody can be used as capture antibody to detect LH in sandwich ELISA application.

References:

If research is published using this product, please inform Anogen in order to cite the reference on this datasheet. Anogen will provide one unit of product in the same category as gratitude.